Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Cytotoxic and phytochemical investigation of cousinia ermenekensis hub.-mor.
Farmacia · Ocak 2020
YÖKSİS Kayıtları
CYTOTOXIC AND PHYTOCHEMICAL INVESTIGATION OF COUSINIA ERMENEKENSIS HUB.-MOR
FARMACIA · 2020 SCI-Expanded
PROFESÖR OSMAN TUGAY →
Makale Bilgileri
DergiFarmacia
Yayın TarihiOcak 2020
Cilt / Sayfa68 · 521-525
Scopus ID2-s2.0-85086905519
Erişim🔓 Açık Erişim
Özet
Cousinia is one of the widespread genera of Asteraceae family. There are numerous studies on this genus and it has not been examined phytochemically in detail. Thus, we aimed to evaluate the phytochemical composition and the cytotoxic effect of Cousinia ermenekensis on human lung cancer (A549), human colon adenocarcinoma (Colo 205), hepatocellular carcinoma (HepG2) cell lines and human bronchial epithelial (Beas-2b) cell line. C. ermenekensis methanol extract showed higher cytotoxic activity against Colo 205 cell line (IC50 = 69 µg/mL). A preliminary examination of the mass spectrums revealed the presence of 13 compounds in the extract. According to the quantitative analyses, the highest content of chlorogenic acid, malic acid, quinic acid and, rutin were detected in extract (28.496, 18.264, 15.115 and 12.506 µg/mg extract respectively).
Yazarlar (4)
1
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
2
Eren Demirpolat
3
Hanifa Fatullayev
4
Osman Tugay
Anahtar Kelimeler
Asteraceae
Cousinia
Cytotoxicity
LC-MS/MS
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
4
Yazar
4
Anahtar Kelime