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Phytochemical composition and cytotoxic activity of four Cousinia Species against human hepatocellular carcinoma (HepG2) cell line

Phytomedicine Plus · Kasım 2021

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YÖKSİS Kayıtları
Phytochemical composition and cytotoxic activity of four Cousinia Species against human hepatocellular carcinoma (HepG2) cell line
Phytomedicine Plus · 2021 DOAJ
PROFESÖR OSMAN TUGAY →
Phytochemical composition and cytotoxic activity of four Cousinia Species against human hepatocellular carcinoma (HepG2) cell line
Phytomedicine Plus · 2021 SCOPUS
PROFESÖR OSMAN TUGAY →

Makale Bilgileri

DergiPhytomedicine Plus
Yayın TarihiKasım 2021
Cilt / Sayfa1
DOI10.1016/j.phyplu.2021.100068
Scopus ID2-s2.0-85125605602
Erişim🔓 Açık Erişim
Özet Background: Cousinia Cass. is one of the most diverse genus of Asteraceae family. According to previous studies some Cousinia species showed significant cytotoxic activity. Purpose: In this study, we aimed to investigate the cytotoxic activity and phytochemical profile of four Cousinia species (C.davisiana Hub.-Mor., C.foliosa Boiss. & Balansa, C.ramosissima DC, C.stenocephala Boiss). Methods: The cytotoxic activity was investigated with SRB method against HepG2 (human hepatocellular carcinoma) cell line. The quantitative and qualitative determination of compounds were carried out by LC-MS/MS. Results: In a result, C. davisiana methanol extract (CD) and ethyl acetate sub-extract (CDE) showed more cytotoxic activity with 150 and 89 µg/ml IC50 values, respectively. The mass spectrums revealed the presence of 15 compounds in CD methanol extract and 9 compounds in active CDE sub-extract. According to quantitative analyses the highest contents of all compounds were detected in CD extract. Conclusion: Moreover, this study on inhibitory activity of CD extract and CDE sub-extract suggests detailed investigation for cytotoxic activity.

Yazarlar (4)

1
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
2
Eren Demirpolat
3
Hanifa Fatullayev
4
Osman Tugay

Anahtar Kelimeler

Asteraceae Cousinia Cytotoxicity HepG2 LC-MS/MS

Kurumlar

Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

2
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

OT
OSMAN TUGAY
PROFESÖR

Hızlı Erişim

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