Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
LC–ESI-MS/MS-BASED PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND ENZYME INHIBITION ACTIVITIES OF EXTRACTS FROM COUSINIA AINTABESIS BOISS. & HAUSSKN.
Farmacia · Ocak 2022
YÖKSİS Kayıtları
LC–ESI-MS/MS-BASED PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND ENZYME INHIBITION ACTIVITIES OF EXTRACTS FROM COUSINIA AINTABESIS BOISS. & HAUSSKN
FARMACIA · 2022 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
CYTOTOXIC AND PHYTOCHEMICAL INVESTIGATION OF COUSINIA ERMENEKENSIS HUB.-MOR
2020 ISSN: 0014-8237 SCI-Expanded Q4
Prof. Dr. OSMAN TUGAY →
CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS.
2019 ISSN: 0014-8237 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
LC–ESI-MS/MS-BASED PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND ENZYME INHIBITION ACTIVITIES OF EXTRACTS FROM COUSINIA AINTABESIS BOISS. & HAUSSKN
2022 ISSN: 0014-8237 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Makale Bilgileri
Dergi
Farmacia
ISSN00148237
Yayın TarihiOcak 2022
Cilt / Sayfa70 · 287-294
Scopus ID2-s2.0-85129723670
Erişim🔓 Açık Erişim
Özet
This study aimed to evaluate the antioxidant activity, the inhibitory effect on digestive enzymes linked to diabetes and the phytochemical composition of an active sub-extract obtained from Cousinia aintabensis (Asteraceae). The antioxidant effect of extracts was investigated with DPPH●, ABTS●+ and FRAP tests and the inhibition effect was tested on α-amylase and α-glucosidase. The quantitative and qualitative determination of the compounds within the active extract was carried out by LC-MS/MS. The highest total phenolic (185.816 ± 0.003 mg GAE/g extract) and total flavonoid content (147.423 ± 0.003 mg CA/g extract) was found in ethyl acetate sub-extract of C. aintabensis (CAE). It also showed the highest antioxidant activity on DPPH● (IC50 = 0.473 ± 0.056 mg/mL), ABTS●+ (at a conc. of 0.5 mg/mL equivalent to 0.543 ± 0.005 µM Trolox) and FRAP (at a conc. of 1 mg/mL equivalent to 2586 ± 6.421 mmol Fe2+) tests. Furthermore, the highest α-amylase and α-glucosidase activity were also found in CAE (IC50 = 0.361 ± 0.010 µg/mL for α-glucosidase and 1.010 ± 0.010 for α-amylase). According to LC-MS/MS analysis, the main compounds of CAE were cynarin and isorhamnetin 3-O-rutinoside.
Yazarlar (3)
1
Fatima Kübra Yilmaz
2
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
3
Osman Tugay
Anahtar Kelimeler
antioxidant
Asteraceae
Cousinia
diabetes
LC-MS/MS
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Farmacia
Q3
SJR Skoru0,251
H-Index33
YayıncıRomanian Society for Pharmaceutical Sciences
ÜlkeRomania
Pharmacology, Toxicology and Pharmaceutics (miscellaneous) (Q3)
Metrikler
3
Atıf
3
Yazar
5
Anahtar Kelime