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Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies

Pharmaceutical Biology · Ocak 2023

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YÖKSİS Kayıtları
Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. Refractum var. torquatum with bioactivity studies
Pharmaceutical Biology · 2023 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
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Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
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Implications from a pharmacogenomic analysis: iNerium oleander/i leaf distillate supplemented diet regulates cholesterol metabolism in rats/title
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Antimicrobial Activities of Some Plants from the Eastern Anatolia Region of Turkey
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Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. Refractum var. torquatum with bioactivity studies
2023 ISSN: 1388-0209 SCI-Expanded Q1
Prof. Dr. OSMAN TUGAY →

Makale Bilgileri

Dergi Pharmaceutical Biology
ISSN13880209
Yayın TarihiOcak 2023
Cilt / Sayfa61 · 907-917
DOI10.1080/13880209.2023.2218881
Scopus ID2-s2.0-85162943202
Erişim🔓 Açık Erişim
Özet Context: The genus Glaucium Mill., one of the important Papaveraceae family plants, is rich in isoquinoline alkaloids and distributed worldwide. Objective: Isolation and identification of bioactive alkaloids from Glaucium grandiflorum Boiss. & Huet. subsp. refractum (Nabelek) Mory var. torquatum (Cullen) Mory and G. corniculatum (L.) Rudolph var. corniculatum (Aslan 2012), and investigation of their antioxidant and anticholinesterase activities. Materials and methods: The aerial parts of each plant were dried, powdered, and percolated with methanol, then each extract was fractionated between 50% aqueous acetic acid and petroleum. Their aqueous acidic layer was adjusted to pH 7–8 with NH4OH and extracted with chloroform, the extract was subjected to CC separation and isolation. Structures of the isolated alkaloids were elucidated by 1D and 2D-NMR and mass spectral analyses. The alkaloid extracts and their pure alkaloids were tested for anti-cholinesterase (AChE and BuChE) and antioxidant (ABTS, CUPRAC, β-carotene linoleic acid tests) activities in vitro. Results: Methanol extracts of Glaucium grandiflorum subsp. refractum var. torquatum and G. corniculatum var. corniculatum afforded a novel compound glauciumoline and seven known isoquinoline alkaloids three of which have an aporphine-type and the other five have a protopine-type skeleton. Among them, trans-protopinium (7) and cis-protopinium (8) were isolated from a Glaucium species for the first time. Tertiary amine extracts (TAEs) of both plants showed very strong acetylcholinesterase inhibitory activity. The TAE of the plants also showed strong antioxidant activity while the isolated alkaloids showed no meaningful activity in the anticholinesterase and antioxidant tests. Discussion and conclusions: Glaucium species are considered promising therapeutic agents in the treatment of Alzheimer’s disease.

Yazarlar (6)

1
Tuba Kusman Saygi
ORCID: 0000-0002-1771-1453
2
Nur Tan
ORCID: 0000-0001-7958-1917
3
Gülbahar Özge Alim Toraman
ORCID: 0000-0002-7816-7551
4
Caglayan Unsal Gurer
ORCID: 0000-0002-8244-4152
5
Osman Tugay
6
Gulacti Topcu

Anahtar Kelimeler

aporphine glaucine Glaucium glauciumoline protopine structure elucidation

Kurumlar

Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Istanbul Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pharmaceutical Biology
Q1 OA
SJR Skoru1,121
H-Index103
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Complementary and Alternative Medicine (Q1)
Drug Discovery (Q1)
Medicine (miscellaneous) (Q1)
Pharmaceutical Science (Q1)
Pharmacology (Q1)
Molecular Medicine (Q2)
Dergi sayfasına git

Metrikler

11
Atıf
6
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

OT
OSMAN TUGAY
Prof. Dr.

Hızlı Erişim

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