Scopus
YÖKSİS Eşleşti
Interaction between ketoconazole and human serum albumin on e oxy modified magnetic nano articles for drug delivery
Journal of Nanoscience and Nanotechnology · Ekim 2013
YÖKSİS Kayıtları
Interaction between ketoconazole and human serum albumin on epoxy modified magnetic nanoparticles for drug delivery
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY · 2013 SCI 18 atıf
PROFESÖR MUSTAFA ÖZMEN →
Interaction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Delivery
Journal of Nanoscience and Nanotechnology · 2013 SSCI 12 atıf
PROFESÖR SEMAHAT KÜÇÜKKOLBAŞI →
Interaction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Delivery
Journal of Nanoscience and Nanotechnology · 2013 SCI-Expanded 6 atıf
PROFESÖR ESRA MALTAŞ ÇAĞIL →
Makale Bilgileri
DergiJournal of Nanoscience and Nanotechnology
Yayın TarihiEkim 2013
Cilt / Sayfa13 · 6522-6528
Scopus ID2-s2.0-84888421378
Özet
Suer aramagnetic iron oxide nano articles (S IONs) were modified with [3-(2,3-e oxy ro oxy) ro yl] trimethoxy silane, which resulted in formation of e oxy grou s on the articles surface. The e oxy functionalized S IONs can bind to human serum albumin (HSA). The binding amount of HSA to e oxy modified S IONs was found to be as 32.7M for 1 mg e oxy modified S IONs at 280 and 342 nm of excitation and emission wavelengths by using fluorescence s ectrosco y. Interaction of ketoconazole with HSA immobilized e oxy functionalized S IONs was studied at 300 and 390 nm of excitation and emission wavelengths, res ectively. Binding mechanism of ketoconazole and HSA was identified by Stern-Volmer equation. Thermodynamic arameters (H,S andG) were also estimated for the interaction. Therefore, the nature of the binding forces was found to be as hydro hobic interaction. rotein and drug attachments were also examined by Infrared s ectrosco y (IR) and Scanning Electron Microsco y (SEM). This study show that re ared albumin-based magnetic nano articles carrier systems re resents an attractive strategy for drug delivery Copyright © 2013 American Scientific Publishers.
Yazarlar (5)
1
Esra Maltas Cagil
2
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
3
Burak Yildirimer
4
Semahat Kucukkolbasi
5
Salih Yildiz
Anahtar Kelimeler
Fluorescence Sectroscoy.
Human Serum Albumin
Ketoconazole
Magnetic Nano articles
Silanization
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
51
Atıf
5
Yazar
5
Anahtar Kelime