Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Electrochemical studies of olmesartan medoxomil and its detection in pharmaceutical dosage forms and biological fluids by cathodic adsorptive stripping voltammetric method
Journal of the Brazilian Chemical Society · Ocak 2014
YÖKSİS Kayıtları
Electrochemical Studies of Olmesartan Medoxomil and its Detection in Pharmaceutical Dosage Forms and Biological Fluids by Cathodic Adsorptive Stripping Voltammetric Method
Journal of the Brazilian Chemical Society · 2014 SCI-Expanded
PROFESÖR SEMAHAT KÜÇÜKKOLBAŞI →
Makale Bilgileri
DergiJournal of the Brazilian Chemical Society
Yayın TarihiOcak 2014
Cilt / Sayfa25 · 920-927
Scopus ID2-s2.0-84902305052
Erişim🔓 Açık Erişim
Özet
The electrochemical properties of olmesartan (OLME) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at hanging mercury drop electrode (HMDE). All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of OLME at about -1.2 and -1.5 V vs. Ag/AgCl at pH 5.0 in Britton-Robinson (BR) buffer. This adsorptive character of the molecule was used to develop a novel, fully validated, rapid, selective and simple differential pulse cathodic adsorptive stripping voltammeric (DPCAdSV) method for the direct determination of OLME in pharmaceutical dosage form and human urine without timeconsuming steps prior to drug assay. Peak current of electrochemical reduction of OLME was found to vary linearly with the concentration in the range from 4.7 × 10-8 mol L-1 (0.0262 μg mL-1) to 8.3 × 10-6 mol L-1 (4.636 μg mL-1). In this method, limit of quantification (LOQ) was found to be 5.1 × 10-7 mol L-1 (0.284 μg mL-1). The method was applied to determine the content of OLME in commercial pharmaceutical preparation and spiked human urine. It was found to be highly accurate and precise, having a relative standard deviation of less than 10% for all applications. © 2014 Sociedade Brasileira de Química.
Yazarlar (4)
1
Funda Öztürk
2
Semahat Kucukkolbasi
3
Ceren Kaçar Selvi
4
Esma Kılıç
Anahtar Kelimeler
Differential pulse cathodic adsorptive stripping voltammetry
Olmesartan
Pharmaceutical dosage form
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Tekirdağ Namık Kemal Üniversitesi
Tekirdag Turkey
Metrikler
8
Atıf
4
Yazar
3
Anahtar Kelime