Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal · Ocak 2017
YÖKSİS Kayıtları
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2017 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal · 2017 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal · 2017 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal · 2017 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2017 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2017 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
The effect of vitamin D on MCF-7 breast cancer cell metabolism
Bratislava Medical Journal · 2017 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2017
Cilt / Sayfa118 · 101-106
Scopus ID2-s2.0-85014924089
Erişim🔓 Açık Erişim
Özet
The role of vitamin D in calcium absorption and bone health is known. The studies revealed that vitamin D modulates breast cancer cell growth and it is also associated with a reduced breast cancer risk. The primary objective of this study was to highlight the metabolic effect of Vitamin D on MCF-7 breast cancer cell line. For that purpose, we checked the apoptosis, energy, amino-acid and acylcarnitine levels in cancer cells, that the study propose, that 1α, 25(OH)2D3 could inhibit cell growth in a dose and time dependent manner. IC50 dose was calculated as 145 nM for vitamin D. We observed the apoptosis level in vitamin D groups, which were 18, 28 and 38.5 % at 24, 48 and 72 hours, respectively. During metabolic screening analysis, it was observed that glutamine, methionine and glutamic acid levels were treated more by Vitamin D groups in cell line and also, that acylcarnitine level was increased in 24 and 48 hour groups when compared to the control, but decreased in 72 hours. Further studies are needed to analyze the role of amino acids and acylcarnitines for early apoptosis and cancer metabolism.
Yazarlar (5)
1
B. Saraçligil
2
Bahadır Öztürk
3
Ali Ünlü
ORCID: 0000-0002-9991-3939
4
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
5
G. Tekin
Anahtar Kelimeler
Amino-acid and acylcarnitine levels
Apoptosis
Energy
Vitamin D
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
5
Yazar
4
Anahtar Kelime