Scopus
YÖKSİS Eşleşti
Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: A pilot study
Clinical Laboratory · Ocak 2019
YÖKSİS Kayıtları
Assessment of Endothelial Dysfunction with Methylated Arginines andL-arginine in Cadmium-Exposed People: a Pilot Study
Clinical Laboratory · 2019 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study
Clinical Laboratory · 2019 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Assessment of Endothelial Dysfunction with Methylated Arginines andL-arginine in Cadmium-Exposed People: a Pilot Study
Clinical Laboratory · 2019 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study
Clinical Laboratory · 2019 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiClinical Laboratory
Yayın TarihiOcak 2019
Cilt / Sayfa65 · 1821-1828
Scopus ID2-s2.0-85073604516
Özet
Background: Workers can be exposed to cadmium (Cd) in various industries. On the other hand, another potential source for Cd exposure is the food chain and smoking. Environmental pollution to Cd plays an important role in the development of atherosclerosis. Asymmetric dimethyl arginine (ADMA) levels promote the development of endothelial dysfunction and atherosclerosis-related diseases such as hypertension, acute coronary syndrome, congestive heart failure, and peripheral vascular diseases. The aim of this study is to evaluate the cardiovascular risks of non-symptomatic cadmium-exposed workers and to promote the value of methylated arginines in screening of toxic exposures. Methods: A total 176 participants were included in the study which has been separated as control group (n = 79) and Cd-exposed group (n = 94). Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used for toxicological analysis of Cd levels. Also, liquid Chromatography-Mass Spectrometry (LC-MS/MS) was used for levels of methylated arginines such as ADMA, symmetric dimethylarginine (SDMA), NG-monomethyl-L-arginine (L-NMMA), homoarginine, and citrulline. Results: Statistically significant differences were observed for control and Cd-exposed groups, respectively as follows: Cd levels (0.25 ± 0.13 µg/L and 1.33 ± 0.61 µg/L), ADMA (0.16 ± 0.04 µmol/L and 0.22 ± 0.11 µmol/L), SDMA (0.21 ± 0.06 µmol/L and 0.27 ± 0.07 µmol/L), L-NMMA(0.02 ± 0.01 µmol/L and 0.03 ± 0.01μmol/L), and arginine/ADMA levels (695.82 ± 620.63 and 478.30 ± 432.61). Conclusions: Our results suggest that workers chronically exposed to Cd showed imbalances in endothelial parameters.
Yazarlar (9)
1
Lutfiye Tutkun
2
Meside Gunduzoz
ORCID: 0000-0001-6140-8331
3
Vugar Ali Turksoy
4
Serdar Deniz
5
Ozgur Oztan
6
Sultan P. Cetintepe
7
Servet Birgin Iritas
8
G. Tekin
9
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Asymmetric dimethyl arginine (ADMA)
Atherosclerosis
Cadmium exposure
Endothelial dysfunction
Methylated arginines
Kurumlar
Ankara Occupational Diseases Hospital
Ankara Turkey
Bozok Üniversitesi
Yozgat Turkey
Gazi Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
HLC Medical Center
Ankara Turkey
Provincial Health Directorate
Malatya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Türkiye Cumhuriyeti adalet bakanliği
Ankara Turkey
Metrikler
3
Atıf
9
Yazar
5
Anahtar Kelime