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Scopus 🔓 Açık Erişim YÖKSİS ISSN Eşleşti SJR Q2

Comparison of anticarcinogenic properties of viburnum opulus and its active compound P-coumaric acid on human colorectal carcinoma

Turkish Journal of Biology · Ocak 2020

YÖKSİS Kayıtları — ISSN Eşleşmesi

C Banded Karyotype and Nucleolar Organizer Regions NORs of Wild Boar Sus scrofa Artiodactyla Suidae from Anatolia

2009 ISSN: 1300-0152 SCI-Expanded 2 atıf

Prof. Dr. ATİLLA ARSLAN →

C and NOR stained karyotypes of mole rat Nannospalax xanthodon 2n 54 from Kirikkale Turkey

2011 ISSN: 1300-0152 SCI-Expanded 7 atıf

Prof. Dr. ATİLLA ARSLAN →

10.3906/biy-1011-2

A comparative study on the fatty acid composition of the oils from five Bupleurum species collected from Turkey

2012 ISSN: 1300-0152 SCI-Expanded

Prof. Dr. ABDURRAHMAN AKTÜMSEK →

Fatty acid composition of the seeds of some species of Peucedanum kral otu from Turkey

2012 ISSN: 1300-0152 SCI-Expanded

Prof. Dr. ABDURRAHMAN AKTÜMSEK →

10.3906/biy-1009-95

Identification and characterization of Mlo genes in pea Pisum sativum L vis à vis validation of Mlo gene specific markers

2015 ISSN: 1300-0152 SCI-Expanded

Prof. Dr. TUNA UYSAL →

Agaricus bisporus Lange Sing un Yağ Asidi Bileşimi

1998 ISSN: 1300-0152 CABI Abstracts on Hygiene and Communicable Diseases (Online) AgBiotechNet Agricultural Economics Database Agroforestry Abstracts (Online) Animal Breeding Abstracts (Online) Animal Science Database Biocontrol News and Information (Online) Botanical Pesticides Abstracts CAB Abstracts (Commonwealth Agricultural Bureaux) Crop Physiology Abstracts (Online) Crop Science Database Dairy Science Abstracts (Online) Environmental Impact Field Crop Abstracts (Online) Forest Products Abstracts Forest Science Database Forestry Abstracts (Online) Global Health Grasslands and Forage Abstract (Online) Horticultural Science Database Irrigation and Drainage Abstract (Online) Maize Abstracts (Online) Nematological Abstracts (Online) Nutrition Abstracts and Reviews. Series B: Livestock Feeds and Feeding (Online) Nutrition and Food Sciences Database Organic Research Database Ornamental Horticulture (Online) Parasitology Database Plant Breeding Abstracts (Online) Plant Genetic Resources Abstracts Plant Genetics and Breeding Database Plant Growth Regulator Abstracts Postharvest Abstracts Potato Abstracts (Online) Poultry Abstracts (Online) Protozoological Abstracts (Online) Review of Medical and Veterinary Entomology (Online) Review of Plant Pathology (Online) Rural Development Abstracts (Online) Seed Abstracts (Online) Soil Science Database Soils and Fertilizers (Online) Soybean Abstracts (Online) Sugar Industry Abstracts (Online) TropAg & Rural Tropical Diseases Bulletin (Online) Veterinary Science Database Weed Abstracts (Online) World Agricultural Economics and Rural Sociology Abstracts (Online) EBSCOhost Academic Search Alumni Edition, 8/1/2002- Academic Search Complete, 8/1/2002- Academic Search Elite, 8/1/2002- Academic Search Premier, 8/1/2002- Academic Search: Main Edition, 8/1/2002- Advanced Placement Source, 8/1/2002- Biological Abstracts (Online) Current Abstracts, 8/1/2002- Energy & Power Source, 6/1/2007- Science and Technology Collection, 8/1/2002- TOC Premier (Table of Contents), 8/1/2002- Elsevier BV BIOBASE Scopus, 2006- Julius Kuehn-Institut, Bundesforschungsinstitut fuer Kulturpflanzen * Institut fuer Rebenzuechtung Geilweilerhof Vitis - Viticulture and Oenology Abstracts (Online) Thomson Reuters Biological Abstracts (Online) BIOSIS Preview

Prof. Dr. GIYASETTİN KAŞIK →

Effects of different genotypes and gamma ray doses on haploidization using irradiated pollen technique in squash

2014 ISSN: 13000152 SCI

Dr. Öğr. Üyesi NAMIK KEMAL YÜCEL →

10.3906/biy-1309-5

Agaricus bisporus Lange Sing un Yağ Asidi Bileşimi

Prof. Dr. CELALEDDİN ÖZTÜRK →

Genetic variability among native dog breeds in Turkey

2013 ISSN: 1300-0152 SCI

Prof. Dr. CAFER TEPELİ →

10.3906/biy-1203-64

Determination of the relationship between some Centaurea species based on SDS PAGE

2010 ISSN: 1300-0152 SCI-Expanded

Prof. Dr. OSMAN TUGAY →

10.3906/biy-0809-15

Comparison of Anticarcinogenic Properties of Viburnum opulus and its Active 1 Compound p-Coumaric Acid on Human Colorectal Carcinoma

2020 ISSN: 1300-0152 SCI-Expanded Q2

Prof. Dr. SERDAR KARAKURT →

A Cytogenetical Study on Some Plants Taxa in Nizip Region (Aksaray, Turkey)

2009 ISSN: 1300-0152 SCI-Expanded

Doç. Dr. ÖZLEM ÇETİN →

10.3906/biy-0805-22

Karyology of the Scorzonera L. (Asteraceae) taxa from Turkey

2012 ISSN: 1300-0152 SCI-Expanded Q3

Doç. Dr. ÖZLEM ÇETİN →

10.3906/biy-1008-46

Antimicrobial and antiviral effects of essential oils from selected Umbelliferae and Labiatae plants and individual essential oil components

2012 ISSN: 1300-0152 SCI Q3

Prof. Dr. YÜKSEL KAN →

10.3906/biy-0912-30

Makale Bilgileri

Dergi Turkish Journal of Biology

ISSN13000152

Yayın TarihiOcak 2020

Cilt / Sayfa44 · 252-263

DOI10.3906/biy-2002-30

Scopus ID2-s2.0-85092484949

Erişim🔓 Açık Erişim

Özet Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticar-cinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active compound, trans-p-coumaric acid (p-CA), on human colon cancer cells (DLD-1, HT-29, SW-620, Caco-2) and healthy colon epithelial cells (CCD-18Co). The effects of EVO on controlled cell death (apoptosis) and the cell division cycle were determined by flow cytometry. Alteration in mRNA and protein expressions of switch genes in colorectal carcinoma (APC, MLH1, TP53, SMAD4, KRAS, and BRAF) were determined by qRT-PCR and Western blot, respectively. Our results show that EVO possesses a strong reducing capacity and free-radical scavenging activity. HPLC analyses prove that p-CAis the main compound of EVO. EVO and p-CA inhibit the proliferation of human colon cancer cells DLD-1 and HT-29 in a dose-dependent manner. EVO increases apoptosis of DLD-1 cells and halts the cell cycle in the G2 stage in HT-29 cells. mRNA and protein expressions of p53 and SMAD-4 are upregulated, while BRAFs are downregulated. The results were directly propor-tional to p-CA. EVO and p-CA up-and downregulate switch genes and protein expressions of DLD-1 cells, which alter the expression of 186 other genes. This is the first study of pharmacological exploration of V.opulus in human colon cancer. Its antiproliferative effects may be due to the presence of p-CA.

Yazarlar (3)

Serdar Karakurt

Gulsum Abusoglu

Zekiye Ceren Arituluk

Anahtar Kelimeler

Apoptosis BRAF Cell cycle Colorectal carcinoma P-coumaric acid TP53 Viburnum opulus

Kurumlar

Hacettepe Üniversitesi

Ankara Turkey

Selçuk Üniversitesi

Selçuklu Turkey

Scimago Dergi (ISSN Eşleşmesi)

Turkish Journal of Biology

SJR Skoru0,321

H-Index55

YayıncıTUBITAK

ÜlkeTurkey

Agricultural and Biological Sciences (miscellaneous) (Q2)

Cell Biology (Q4)

Genetics (Q4)

Microbiology (Q4)

Molecular Biology (Q4)

Physiology (Q4)

Dergi sayfasına git

Metrikler

Atıf

Yazar

Anahtar Kelime

Sistemimizdeki Yazarlar

GÜLSÜM ABUŞOĞLU

Doç. Dr.

Hızlı Erişim

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