Scopus
YÖKSİS Eşleşti
Total methylated arginine load as a risk parameter in subjects with masked hypertension
Clinical and Experimental Hypertension · Şubat 2020
YÖKSİS Kayıtları
Total methylated arginine load as a risk parameter in subjects with masked hypertension
Clinical and Experimental Hypertension · 2020 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Total methylated arginine load as a risk parameter in subjects with masked hypertension
Clinical and Experimental Hypertension · 2020 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
Total methylated arginine load as a risk parameter in subjects with masked hypertension
Clinical and Experimental Hypertension · 2020 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Total methylated arginine load as a risk parameter in subjects with masked hypertension
Clinical and Experimental Hypertension · 2019 SCI-Expanded
PROFESÖR KENAN DEMİR →
Makale Bilgileri
DergiClinical and Experimental Hypertension
Yayın TarihiŞubat 2020
Cilt / Sayfa42 · 126-130
Scopus ID2-s2.0-85062444792
Özet
Asymmetric dimethylarginine, symmetric dimethylarginine, and L-monomethylarginine are originated from the subsequent proteolytic catalysis of methylated arginine residues on different proteins and inhibit the endogenous nitric oxide generation. The changes in total methylarginine load (Asymmetric dimethylarginine plus symmetric dimethylarginine plus L-monomethylarginine) may contribute to hypertension. The aim of this study was to determine serum methylarginine concentrations in patients with masked hypertension and determine the association between these biomarkers and blood pressure measurements. Control group, masked hypertension and hypertension groups consisted of 40 subjects (11 males, 28 females, mean age 48.6 ± 13.1), 28 subjects (14 males, 14 females, mean age 50.9 ± 11.0) and 36 subjects (15 males, 21 females, mean age 54.4 ± 12.3 years), respectively (P= 0.149). Serum total methylarginine load was significantly higher in hypertension group (0.63 ± 0.23) compared to masked hypertension (0.49 ± 0.16) and control groups (0.38 ± 0.13) (P= 0.008 and P< 0.001). While there was no statistically significant difference between healthy control groups [0.147 (0.03–0.29)] and masked hypertension patients [0.144 (0.05–0.42)] for serum symmetric dimethylarginine levels (P= 0.970), it was markedly elevated in hypertension group [0.25 (0.07–0.54)] compared to masked hypertension group [0.14 (0.05–0.42)] (P= 0.001). Serum total methylarginine load was positively correlated with night-time SBP (r = 0.214, P= 0.029). Serum methylarginine levels might be a useful marker for determining the courses of clinical hypertension.
Yazarlar (7)
1
Muserref Hosaf
2
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
3
Ahmet Avcı
4
Kenan Demir
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Duygu Eryavuz
7
Gulsum Abusoglu
Anahtar Kelimeler
blood pressure
masked hypertension
Symmetric dimethylarginine
tandem mass spectrometry
total methylarginine load
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
7
Yazar
5
Anahtar Kelime