Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method
Journal of Pharmaceutical and Biomedical Analysis · Şubat 2020
YÖKSİS Kayıtları
The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2020 SCI-Expanded
Prof. Dr. MEMDUHA AYDIN →
The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2020 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
The relationship between serum clozapine concentrations andhematological parameters by a validated mass spectrometric method
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2020 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2020 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
The relationship between serum clozapine concentrations andhematological parameters by a validated mass spectrometric method
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2020 SCI-Expanded
Doç. Dr. GÜLSÜM ABUŞOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and validation of UFLC MS MS method for determination of bosentan in rat plasma
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Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
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Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
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Paeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assays
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Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations
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Identification of phenolic components via LC–MS analysis and biological activities of two Centaurea species: C. drabifolia subsp. drabifolia and C. lycopifolia
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Influence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applications
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Chemical profiling of Centaurea bornmuelleri Hausskn. aerial parts by HPLC-MS/MS and their pharmaceutical effects: From nature to novel perspectives
2019 ISSN: 0731-7085 SCI-Expanded Q2
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A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties
2019 ISSN: 0731-7085 SCI-Expanded Q2
Prof. Dr. GÖKHAN ZENGİN →
The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method
2020 ISSN: 0731-7085 SCI-Expanded
Prof. Dr. MEMDUHA AYDIN →
Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç Aksoy: An endemic plant from Turkey
2019 ISSN: 0731-7085 SCI
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Investigation of chemical profile, biological properties of Lotus corniculatus L. extracts and their apoptotic-autophagic effects on breast cancer cells
2019 ISSN: 0731-7085 SCI
Prof. Dr. GÖKHAN ZENGİN →
Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç Aksoy: An endemic plant from Turkey
2019 ISSN: 0731-7085 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
The relationship between serum clozapine concentrations andhematological parameters by a validated mass spectrometric method
2020 ISSN: 0731-7085 SCI-Expanded Q2
Doç. Dr. GÜLSÜM ABUŞOĞLU →
HPLC-FRAP methodology and biological activities of different stem bark extracts of Cajanus cajan (L.) Millsp.
2020 ISSN: 0731-7085 SCI-Expanded Q2
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Identification of bioactive compounds from Rhaponticoides iconiensis extracts and their bioactivities: An endemic plant to Turkey flora
2020 ISSN: 0731-7085 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
Network analysis, chemical characterization, antioxidant and enzyme inhibitory effects of foxglove (Digitalis cariensis Boiss. ex Jaub. & Spach): A novel raw material for pharmaceutical applications
2020 ISSN: 0731-7085 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
2021 ISSN: 0731-7085 SCI-Expanded Q2
Prof. Dr. ALİ ÜNLÜ →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
2021 ISSN: 0731-7085 SCI-Expanded Q2
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
2021 ISSN: 0731-7085 SCI-Expanded Q2
Prof. Dr. ALİ ÜNLÜ →
Makale Bilgileri
ISSN07317085
Yayın TarihiŞubat 2020
Cilt / Sayfa180
Scopus ID2-s2.0-85076920327
Özet
Objective: Clozapine is one of the most effective drugs for resistant schizophrenia, but its severe metabolic and hematological side effects limit the use of clozapine. It has been reported that clozapine blood concentrations should be maintained between 350−600 ng/mL. Our aim was to develop a determination method for clozapine and its main metabolites norclozapine and clozapine-N-oxide, to perform validation studies and to investigate the change of various biochemical parameters in patients using clozapine. Methods: A liquid chromatography-tandem mass spectrometry (LC–MS/MS) method was developed and validated for clozapine measurement. Thus, blood samples were collected from 38 patients with schizophrenia and 32 healthy volunteers. Biochemical and hematological parameters were measured by Beckman-Coulter AU 5800 (Beckman Coulter, Brea, USA) and Beckman Coulter LH 780 analyzer (Beckman Coulter, Miami, FL, USA), respectively. Hormone levels were analyzed using Cobas 6000 analyzer (Roche Diagnostics, Germany). Results: The LC[sbnd]MS/MS method was linear between 1.22−2500 ng/mL (r2 = 0.9971) for clozapine. The retention times of clozapine, norclozapine and clozapine-N-oxide were 0.92, 0.89 and 0.95, respectively. Blood glucose (GLU) (p = 0.025), low density lipoprotein (LDL-cholesterol) (p = 0.015), triglyseride (TG) (p = 0.042) and total cholesterol (TC) (p = 0.024) levels were higher; hemoglobin (HGB) (0.015), mean corpuscular hemoglobin (MCH) (0.036), red blood cell count (RBC) (0.020), neutrophil (NEU) (0.034), and platelet (PLT) (P = 0.005) levels were lower in the clozapine group. Conclusions: This LC–MS/MS method was rapid, simple, cost-effective and suitable for the routine clozapine monitoring. Furthermore, norclozapine and clozapine-N-oxide were also determined. Monitoring of metabolic and hematological parameters with clozapine levels is very important. However, the limitations of the study were that the method was not validated for norclozapine and clozapine-N-oxide, so the validation parameters were not evaluated for these two metabolites.
Yazarlar (8)
1
Karam Mazin Kamil Gharab
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
4
Memduha Aydin
5
Abdullah Sivrikaya
6
Oguzhan Tok
7
Gulsum Abusoglu
8
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Clozapine
Side effects
Tandem mass spectrometry
Therapeutic drug monitoring
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Pharmaceutical and Biomedical Analysis
Q2
SJR Skoru0,628
H-Index154
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Clinical Biochemistry (Q2)
Drug Discovery (Q2)
Pharmaceutical Science (Q2)
Spectroscopy (Q2)
Metrikler
13
Atıf
8
Yazar
4
Anahtar Kelime