Scopus
YÖKSİS Eşleşti
Assessment of potential cardiovascular risk in trichloroethylene exposure by serum methylated arginine levels
International Journal of Environmental Health Research · Ocak 2021
YÖKSİS Kayıtları
Assessment of potential cardiovascular risk in trichloroethylene exposure by serum methylated arginine levels
International Journal of Environmental Health Research · 2021 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Assessment of potential cardiovascular risk in trichloroethylene exposure by serum methylated arginine levels
International Journal of Environmental Health Research · 2021 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiInternational Journal of Environmental Health Research
Yayın TarihiOcak 2021
Cilt / Sayfa31 · 63-74
Scopus ID2-s2.0-85068025921
Özet
Trichloroethylene (TCE) is a widely used solvent in industrial applications and has toxic effects on various systems. Methylated arginine amino acids (eg asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA)) cause the development of cardiovascular disease by inhibiting NO synthesis, which is considered to be heart-protector. The aim of this study is to determine the risk of cardiovascular diseases in TCE exposure by methylated arginine biomarkers. About 98 controls and 100 TCE-exposed male subjects were included in the study. Trichloroacetic acid (urinary metabolite of TCE), arginine, homoarginine, citrulline ADMA, SDMA, and N-monomethyl L-arginine (L-NMMA) levels were found significantly higher than control group (p < 0.001). The strongest correlation was found between ADMA and Trichloroacetic acid (TCA) level (r = 0.453, p < 0.01). Long-term TCE exposure, may be an important risk factor for cardiovascular diseases by increasing methylated arginine levels.
Yazarlar (9)
1
Servet Birgin Iritas
2
Aybike Dip
3
Meside Gunduzoz
ORCID: 0000-0001-6140-8331
4
Lutfiye Tutkun
5
Vugar Ali Turksoy
6
Serdar Deniz
7
G. Tekin
8
Ozgur Oztan
9
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
arginine
Asymmetric dimethylarginine (ADMA)
cardiovascular risk
symmetric dimethylarginine (SDMA)
trichloroethylene (TCE) toxicity
Kurumlar
Ankara Occupational Diseases Hospital
Ankara Turkey
Bozok Üniversitesi
Yozgat Turkey
HLC Medical Center
Ankara Turkey
Provincial Health Directorate
Malatya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Türkiye Cumhuriyeti adalet bakanliği
Ankara Turkey
Metrikler
3
Atıf
9
Yazar
5
Anahtar Kelime