Scopus
YÖKSİS Eşleşti
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · Ekim 2021
YÖKSİS Kayıtları
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · 2021 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · 2021 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · 2021 SCI-Expanded
PROFESÖR FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · 2021 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters
Journal of Pharmaceutical and Biomedical Analysis · 2021 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiEkim 2021
Cilt / Sayfa205
Scopus ID2-s2.0-85112104961
Özet
Objectives: The study aimed to develop a validated LC–MS / MS method for the measurement of carbamazepine and carbamazepine-10,11-epoxide (CBZE) levels, to compare the carbamazepine concentrations measured by AbSciex API 3200 LC–MS/MS and Beckman Coulter Emit® 2000 immunoassay and to investigate the effect of carbamazepine concentrations on various hematological and biochemical parameters. Methods: For the measurement of carbamazepine and CBZE levels, a validated LC–MS / MS method was developed. Serum carbamazepine levels of patients were measured by AbSciex API 3200 LC–MS / MS and Beckman Coulter Emit® 2000 immunoassay. Biochemical, hematological parameters, and hormone levels were measured by Beckman-Coulter AU 5800 (Beckman Coulter, Brea, USA), Beckman Coulter LH 780 (Beckman Coulter, Miami, FL, USA), and Cobas 6000 (Roche Diagnostics, Germany) analyzers, respectively. Results: The imprecision values for all analytes were less than 7.0 %. The correlation coefficient between the methods was 0.981 (95 % confidence interval: 0.975 to 0.985). Linear regression analysis demonstrated highly significant associations of carbamazepine concentrations with albumin (B = −0.300, p = 0.040), calcium (B = −0.262, p = 0.004), phosphorus (B = −0.241, p = 0.022), WBC (B = −0.288, p = <0.001), PLT (B = −0.236, p = 0.003), RBC (B = −0.257, p = 0.001), NEU% (B = −0.289, p = <0.001), LYM% (B = −0.268, p = 0.001), D vitamini (B = −0.344, p = 0.006) levels. Conclusions: A robust, rapid, and simple method has been developed. Our study revealed that carbamazepine and its metabolite have a significant correlation and likely impact on bone metabolism, blood cell counts, serum protein, albumin levels, and electrolyte concentrations.
Yazarlar (6)
1
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
2
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
3
Bahadır Öztürk
4
Gulsum Abusoglu
5
Fatma Humeyra Yerlikaya
6
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Biochemical parameters
Carbamazepine
Method validation
Tandem mass spectrometry
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
6
Yazar
4
Anahtar Kelime