Scopus
YÖKSİS Eşleşti
Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma
Intensive Care Medicine · Mart 2001
YÖKSİS Kayıtları
Effects of Magnesiumsulfate on Tissue Lactate and Malondialdehyde Levels in Experimental Head Trauma
Intensive Care Medicine · 2001 SCI-Expanded 57 atıf
PROFESÖR HÜSAMETTİN VATANSEV →
Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma
Intensive Care Medicine · 2001 SCI-Expanded
PROFESÖR AHMET AK →
Effects of magnesium sulfate on tissue lactate and malondialdehydelevels in experimental head trauma
INTENSIVE CARE MEDICINE · 2001 SCI
PROFESÖR HÜSAMETTİN VATANSEV →
Makale Bilgileri
DergiIntensive Care Medicine
Yayın TarihiMart 2001
Cilt / Sayfa27 · 264-268
Scopus ID2-s2.0-0035105583
Özet
Objective: To determine the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels in rabbit brain after experimental head trauma. Design: Prospective, randomized trial. Subjects: Thirty New Zealand rabbits. Interventions: Group 1 (n = 10) was the sham operated group. Group 2 (n = 10) (untreated group) and group 3 (n = 10) received head trauma with the weight drop method. MgSO4 was administered 100 mg/kg (15%) i.v. immediately after the head trauma to group 3. Trauma was applied to one side. The non-contused side was named as "a" and the contused side as "b". Measurements: One hour after trauma, brain cortices were resected and the concentrations of lactate and MDA were determined using the spectrophotometric enzymatic and thiobarbituric acid methods. One-way ANOVA and Tukey's HSD tests were used for the evaluation of the results. P < 0.05 was considered as significant. Pearson's correlation test was used between lactate and MDA levels (P < 0.001). Results: There were significant differences between MDA and lactate levels of group 1 and all other groups; non-contused (a) and contused (b) sides of groups 2 and 3; groups 2b-3a, 2b-3b (P < 0.05). The difference in MDA levels was significant between groups 2a-3b (P < 0.05). Correlation between lactate and MDA was very good in group 1, and excellent in groups 2a, 2b, 3a, and 3b. Conclusions: These results demonstrate that head trauma leads to an increase in brain tissue lactate and MDA levels, and MgSO4 suppresses the rise in contused tissue when given after head trauma.
Yazarlar (5)
1
Mehmet E. Ustün
2
Mehmet Gürbilek
3
Ahmet Ak
4
Hüsamettin Vatansev
5
Ates Duman
Anahtar Kelimeler
Head trauma
Lactate
Lipid peroxidation
Magnesium sulfate
Malondialdehyde
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
41
Atıf
5
Yazar
5
Anahtar Kelime