Scopus
Oxidative stress in childhood obesity
Journal of Pediatric Endocrinology and Metabolism · Ocak 2004
Makale Bilgileri
DergiJournal of Pediatric Endocrinology and Metabolism
Yayın TarihiOcak 2004
Cilt / Sayfa17 · 1063-1068
Scopus ID2-s2.0-4444356393
Özet
Objective: To measure products of free radical damage in childhood obesity. Methods: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. Results: D-Roms levels were higher in the obese children than in the non-obese group (33.3 ± 10.1 mg% of H2O2 vs 22.8 ± 2.8 mg% of H2O2; p <0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6 ± 3.1 mg% of H2O2 vs 27.8 ± 3.2 mg% of H2O2; p <0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p <0.001) and serum total cholesterol (p <0.001), with the total variance explained being 82%. Conclusion: Our study demonstrates for the first time that there was increased D-Roms levels in obese children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity. © Freund Publishing House Ltd., London.
Yazarlar (3)
1
M. E. Atabek
2
Hüsamettin Vatansev
3
Ibrahim Erkul
Anahtar Kelimeler
Childhood obesity
Free radicals
Hyperlipidemia
Oxidative stress
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
61
Atıf
3
Yazar
4
Anahtar Kelime