Scopus
YÖKSİS Eşleşti
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · Temmuz 2013
YÖKSİS Kayıtları
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · 2013 SCI-Expanded 3 atıf
PROFESÖR HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · 2013 SCI-Expanded 3 atıf
PROFESÖR ALİ ÜNLÜ →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · 2013 SCI-Expanded 3 atıf
PROFESÖR BAHADIR ÖZTÜRK →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · 2013 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi · 2013 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
Turkish Journal of Biochemistry · 2013 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiTemmuz 2013
Cilt / Sayfa38 · 169-175
Scopus ID2-s2.0-84879973787
Özet
Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disease and it is associated with premature atherosclerosis development. RA patients have multiple factors to develop premature atherosclerosis. Enhanced asymmetric dimethylarginine (ADMA) is considered as a risk factor for the development of atherosclerosis by inducing endothelial dysfunction. The aim of this study was to investigate the role of asymmetric dimethylarginine, arginine and citrulline levels in patients with RA and their relation to the disease activity parameters for possible role on the disease activity. Methods: 92 patients with RA and 34 healthy controls were included the study. Patients and control blood samples collected for ADMA, arginine and citrulline levels. ADMA, arginine and citrulline levels were measured by pre-column derivatization fluorescence HPLC method. CRP and ESR levels examined on the same day were taken from the patient records. Results: While ADMA levels significantly increased, arginine levels decreased in the patient group. There was no difference in citrulline levels between both groups. Only citrulline and arginine showed a weak positive correlation. ADMA, arginine, and citrulline levels showed no correlation with either biochemical parameters such as CRP or ESR, or disease activity or disease severity. Conclusion: Our study has shown that an increase in ADMA levels with the decrease in arginine levels suggests an increase in arginine turnover to ADMA. Increased ADMA levels can be used for an increased risk for premature development of atherosclerosis in patients with RA. Since high ADMA levels prevent the NO-dependent vasodilatation, a possible role of ADMA in development of premature atherosclerosis may be independent from inflammation.
Yazarlar (7)
1
Hüsamettin Vatansev
2
Bahadır Öztürk
3
Sema Yılmaz
ORCID: 0000-0003-4277-3880
4
Abdullah Sivrikaya
5
Mehmet Dagli
6
Aysel Kiyici
7
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
ADMA
Arginine
Citrulline
CRP
Rheumatoid arthritis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
7
Yazar
5
Anahtar Kelime