Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Growth-differentiation factor-15 and tissue doppler imaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
Clinical Biochemistry · Temmuz 2013
YÖKSİS Kayıtları
Growth differentiation factor 15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
Clinical biochemistry · 2013 SCI-Expanded 2 atıf
Prof. Dr. YAVUZ KÖKSAL →
Growth differentiation factor 15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
Clinical Biochemistry · 2013 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Impaired kynurenine metabolism in patients with primary Sjögren’s syndrome
2023 ISSN: 0009-9120 SCI-Expanded Q2
Prof. Dr. ALİ ÜNLÜ →
Growth differentiation factor 15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
2013 ISSN: 0009-9120 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Stability of urine specimens stored with and without preservatives at room temperature and on ice prior to urinalysis
2015 ISSN: 00099120 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
Plasma netrin-1 levels significantly increase in smokers
2016 ISSN: 00099120 SCI-Expanded
Prof. Dr. KAMİLE MARAKOĞLU →
Growth differentiation factor 15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
2013 ISSN: 0009-9120 SCI-Expanded 2 atıf
Prof. Dr. YAVUZ KÖKSAL →
Impaired Kynurenine Metabolism in Patients with Primary Sjögren’s Syndrome
2023 ISSN: 0009-9120 SCI-Expanded
Prof. Dr. SEMA YILMAZ →
Impaired kynurenine metabolism in patients with primary Sjogren ¨ ’s syndrome
2023 ISSN: 0009-9120 SCI-Expanded Q2
Doç. Dr. GÜLSÜM ABUŞOĞLU →
Impaired kynurenine metabolism in patients with primary Sjo spacing diaeresis gren's syndrome
2023 ISSN: 0009-9120 SCI Q2
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Impaired kynurenine metabolism in patients with primary Sjögren’s syndrome
2023 ISSN: 0009-9120 SCI-Expanded Q2
Prof. Dr. ALİ ÜNLÜ →
Impaired kynurenine metabolism in patients with primary Sjögren’s syndrome
2023 ISSN: 0009-9120 SCI-Expanded Q2
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Impaired kynurenine metabolism in patients with primary Sjögren’s syndrome
2023 ISSN: 0009-9120 SCI-Expanded Q2
Prof. Dr. SEDAT ABUŞOĞLU →
Makale Bilgileri
Dergi
Clinical Biochemistry
ISSN00099120
Yayın TarihiTemmuz 2013
Cilt / Sayfa46 · 1239-1243
Scopus ID2-s2.0-84882886785
Özet
Objectives: Anthracyclines have led to an increased risk of cardiac morbidity and mortality. Late cardiac complications in cancer survivors may develop from subclinical myocardial damage. Tissue Doppler imaging (TDI) also has potential as a clinically useful technique for the assessment of myocardial function. Biochemical markers may be used to detect cardiac damage growth-differentiation factor-15 (GDF-15) and are emerging as a biomarker of cardiac dysfunction. The aim of this study is to assess the value of the plasma levels of GDF-15 and TDI in detecting late myocardial dysfunction in childhood cancer survivors (CCS) who were treated with anthracyclines. Design and methods: Thirty-eight CCS who had completed chemotherapy treatment with anthracyclines were included in this study. Control group consisted of 32 age- and gender-matched healthy volunteers. All children underwent a detailed echocardiography, which contained an M-mode, pulse Doppler and tissue Doppler imaging. However, GDF-15 and cardiac troponin. -I (cTnI) were measured. Results: Although, systolic function of the left ventricular was similar in all groups, there were significant differences between parameters of diastolic function of the heart. The mitral valve E wave, E/A ratio, left ventricular E'm wave, and E'm/A'm ratio were different in the patients than in the controls (p=0.049, p=0.037, p<. 0.0001, p=0.001, respectively). The tricuspid valve E/A ratio, right ventricular E't wave, and E't/A't ratio in the patients were also different from those of the controls (p=0.031, p<. 0.0001, p<. 0.0001, respectively). Mean plasma GDF-15 was significantly higher in patients than healthy controls (p=0.027). There were no significant differences in cTnI between both groups. Conclusions: Growth-differentiation factor-15 level may be used as a biomarker of anthracycline-induced cardiovascular disease severity in the CCS. © 2013 The Canadian Society of Clinical Chemists.
Yazarlar (8)
1
Derya Arslan
2
Tugba Cihan
3
Dogan Kose
4
Hüsamettin Vatansev
5
Derya Çimen
6
Yavuz Koksal
7
B. Oran
8
Fikret Akyürek
Anahtar Kelimeler
Anthracyclines
Cardiotoxicity
Childhood cancer survivors
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Clinical Biochemistry
Q2
SJR Skoru0,613
H-Index130
YayıncıElsevier Inc.
ÜlkeUnited States
Clinical Biochemistry (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
19
Atıf
8
Yazar
3
Anahtar Kelime