Scopus
YÖKSİS Eşleşti
Effects of prednisolone, L-asparaginase, gemfibrozil, and combinations of these elements on mice lipid profile, liver, and pancreas
Journal of Pediatric Hematology/Oncology · Ocak 2016
YÖKSİS Kayıtları
Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas
Journal of Pediatric Hematology/Oncology · 2016 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Effects of prednisolone, L-asparaginase, gemfibrozil, and combinations of these elements on mice lipid profile, liver, and pancreas
Journal of Pediatric Hematology/Oncology · 2016 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Effects of Prednisolone L Asparaginase Gemfibrozil and Combinations of These Elements on Mice Lipid Profile Liver and Pancreas
Journal of Pediatric Hematology/Oncology · 2015 SSCI
PROFESÖR HÜSAMETTİN VATANSEV →
Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas
Ovid Technologies (Wolters Kluwer Health) · 2016 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Effects of Prednisolone L Asparaginase Gemfibrozil and Combinations of These Elements on Mice Lipid Profile Liver and Pancreas
Journal of Pediatric Hematology/Oncology · 2016 SCI
PROFESÖR HÜSAMETTİN VATANSEV →
Effects of Prednisolone L Asparaginase Gemfibrozil and Combinations of These Elements on Mice Lipid Profile Liver and Pancreas
Journal of Pediatric Hematology/Oncology · 2016 SCI
PROFESÖR NEVZAT SERDAR UĞRAŞ →
Effects of Prednisolone L Asparaginase Gemfibrozil and Combinations of These Elements on Mice Lipid Profile Liver and Pancreas
Journal of Pediatric Hematology/Oncology · 2016 SCI
PROFESÖR YAVUZ KÖKSAL →
Effects of Prednisolone L Asparaginase Gemfibrozil and Combinations of These Elements on Mice Lipid Profile Liver and Pancreas
Journal of Pediatric Hematology/Oncology · 2016 SSCI
PROFESÖR YAVUZ KÖKSAL →
Makale Bilgileri
DergiJournal of Pediatric Hematology/Oncology
Yayın TarihiOcak 2016
Cilt / Sayfa38 · e42-e49
Scopus ID2-s2.0-84952863927
Özet
The aim of this study is to determine the effects of Lasparaginase (L-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the L-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the L-ASPonly groups. CSs and L-ASP were significantly effective in liver necrosis, L-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or L-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.
Yazarlar (9)
1
Dogan Kose
2
Nuriye Tarakci
3
Zeliha Esin Celik
4
Hüsamettin Vatansev
5
E. A. Cimbek
6
Serdar Uğraş
7
Y. Şen
8
Ümran Çalişkan
9
Yavuz Koksal
Anahtar Kelimeler
Asparaginase
Gemfibrozil
Lipid
Prednisolone
Kurumlar
Faculty of Medicine
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
9
Yazar
4
Anahtar Kelime