Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis
Clinical Rheumatology · Mayıs 2020
YÖKSİS Kayıtları
The clinical value of interleukins-8, -10, and -17 in idiopathicgranulomatous mastitis
Clinical Rheumatology · 2020 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The evaluation of carotid intima-media thickness in children with familial Mediterranean fever
2008 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. FATİH KARA →
Henoch Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year period
2008 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. FATİH KARA →
Comparison of the effects of two antidepressants on exercise performanceof the female patients with fibromyalgia
2006 ISSN: 0770-3198 SSCI 14 atıf
Prof. Dr. NİLSEL OKUDAN →
The evaluation of carotid intima media thickness in children with familial Mediterranean fever
2008 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HARUN PERU →
HLA class 1 associations in Henoch Schonlein purpura increased and decreased frequencies
2007 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HARUN PERU →
Henoch Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year period
2008 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HARUN PERU →
Axial Psoriatic Arthritis: The Impact of Underdiagnosed Disease on Outcomes in Real Life
2018 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. SEMA YILMAZ →
Demographic and clinical characteristics of patients with serum sickness-like reaction
2018 ISSN: 0770-3198 SCI
Prof. Dr. AHMET SERT →
Demographic and clinical characteristics of patients with serum sickness-like reaction
2018 ISSN: 0770-3198 SCI
Prof. Dr. ALAADDİN YORULMAZ →
Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever
2009 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HARUN PERU →
Evaluation of hematological parameters in children with FMF
2019 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HARUN PERU →
Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever
2009 ISSN: 0770-3198 SCI-Expanded 10 atıf
Prof. Dr. YAVUZ KÖKSAL →
The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis
2020 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Clinical features and outcome of MIS-C patients: an experience from Central Anatolia
2021 ISSN: 0770-3198 SCI-Expanded Q3
Prof. Dr. RESUL YILMAZ →
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
2021 ISSN: 0770-3198 SCI-Expanded Q3
Doç. Dr. DİLEK ERGÜN →
Evaluation of Serum Interleukin-6 (IL-6), IL-13 and IL-17 Levels and Computed Tomography Finding in Interstitial Lung Disease Associated with Cönnective Tissue Disease Patients
2021 ISSN: 0770-3198 SCI-Expanded Q3
Prof. Dr. SEMA YILMAZ →
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
2021 ISSN: 0770-3198 SCI-Expanded Q3
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia
2005 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. FUNDA LEVENDOĞLU →
’’Mortality in Psoriatic Arthritis Patients, Changes over Time, and the Impact of COVID‑19: Results from a Multicenter Psoriatic Arthritis Registry (PsART‑ID)
2023 ISSN: 0770-3198 SCI-Expanded
Prof. Dr. SEMA YILMAZ →
Evaluation of the international severity score for FMF (ISSF) scores in Turkish children diagnosed with FMF: a single-center experience
2021 ISSN: 0770-3198 SCI-Expanded Q3
Dr. Öğr. Üyesi FATİH MEHMET AKİF ÖZDEMİR →
Makale Bilgileri
Dergi
Clinical Rheumatology
ISSN07703198
Yayın TarihiMayıs 2020
Cilt / Sayfa39 · 1671-1677
Scopus ID2-s2.0-85077633123
Özet
Introduction: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory benign breast disease. Although the etiology of this disease is unknown, it has been suggested that hormonal disorders, autoimmunity, smoking, and α1-antitrypsin deficiency may play a role in the etiopathogenesis. The aim is to investigate the changes in cytokine profiles including interleukin (IL)-4, -8, -10, -17, and tumor necrosis factor (TNF)-alpha in patients with IGM. Methods: Forty-seven patients with pathologically diagnosed IGM and 30 healthy women were included. The cytokines including IL-4, -8, 10, -17, and TNF-alpha were measured by human enzyme-linked immunosorbent assay. Results: The IL-8, IL-10, and IL-17 levels were higher in IGM patients than control group (p =.002; p =.008; and p =.018, respectively). The IL-8 levels of patients with active lesions and in remission were statistically higher than the control group (p =.027 and p =.015, respectively). IL-10 levels of patients in remission were higher than the control group (p =.024). There was no difference in IL-4 and TNF-ɑ levels between all groups. Conclusion: These results showed that proinflammatory cytokines including IL-8 and IL-17 have role in pathogenesis of IGM. However, the increased levels of IL-10 in especially patients in remission suggest that it reduces the release of proinflamatory cytokines as well as suppressing their function and activation for controlling IGM. Although IGM is thought to be a surgical disease, these cytokine changes indicate the presence of serious immune dysregulation. This suggests that in the treatment of IGM, treatment needs to evolve from surgery to medical treatment.Key points• The IL-8, IL-10, and IL-17 levels were higher in IGM patients than in control group.• The IL-8 levels of both patients with active lesions and in remission were high.• There was no difference in IL-4 and TNF-ɑ levels between all groups.
Yazarlar (4)
1
H. Koksal
2
Hüsamettin Vatansev
3
Hasibe Artac
4
Naim Kadoglou
Anahtar Kelimeler
Cytokine
Etiology
Idiopathic granulomatous mastitis
Prognosis
Kurumlar
Northwick Park Hospital
Harrow United Kingdom
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Clinical Rheumatology
Q2
SJR Skoru0,855
H-Index104
YayıncıSpringer Science and Business Media Deutschland GmbH
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Rheumatology (Q2)
Metrikler
58
Atıf
4
Yazar
4
Anahtar Kelime