Scopus
YÖKSİS Eşleşti
Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers
American Journal of Perinatology · Aralık 2021
YÖKSİS Kayıtları
Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers
American Journal of Perinatology · 2021 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Makale Bilgileri
DergiAmerican Journal of Perinatology
Yayın TarihiAralık 2021
Cilt / Sayfa38 · 1494-1499
Scopus ID2-s2.0-85090305960
Özet
Objective Smoking during pregnancy has harmful effects on the fetus and infant. Although some studies suggest that exposure to fetal-maternal smoking adversely affects both fetal growth and cardiovascular development, the mechanisms and biochemical consequences of smoking in pregnancy and newborns are not yet fully understood. We aimed to investigate whether maternal smoking during pregnancy causes fetal cardiovascular effect by measuring serum asymmetric dimethylarginine (ADMA) level and abdominal aortic intima-media thickness (aIMT). Study Design This prospective study was conducted in newborns of smoking mothers and never-smoker control mothers during their pregnancies. The babies were evaluated echocardiographically on the first day following birth. In two-dimensional mode, abdominal aIMT measurements were performed. ADMA was measured in umbilical cord blood at birth. Results There were 25 mothers in the study group and 25 mothers in the control group. Serum ADMA levels were 0.459 ± 0.119 μmol/L in the study group and 0.374 ± 0.1127 μmol/L in the control group (p = 0.034). The aIMT value in the study group was 0.84 ± 0.026 mm and the aIMT value in the control group was 0.63 ± 0.011 mm (p = 0.005). Conclusion We found that both the serum ADMA and the aIMT significantly increased in the group with newborns of smoker mothers compared with the group of the newborns of never-smoker mothers. It may also be suggested that exposure to fetal-maternal smoking adversely affects cardiovascular development. Key Points It is a known fact that smoking during pregnancy has harmful effects on the development of the fetus and infant. We found that both the serum ADMA and aIMT were significantly higher in the group of infants of smoker mothers.
Yazarlar (6)
1
Huseyin Samet Ozcelik
2
Derya Arslan
3
Cigdem Damla Deniz
4
Oğuzhan Günenç
5
Hüsamettin Vatansev
6
Celil Uysal
Anahtar Kelimeler
abdominal aortic intima-media thickness
ADMA
newborn
pregnancy
smoking
Kurumlar
Dr Ali Kemal Belviranli Hospital for Obstetrics and Pediatrics
Konya Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Patnos State Hospital, Agri
Agri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey