Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Scandinavian Journal of Immunology · Ocak 2022
YÖKSİS Kayıtları
Correlation of myeloid\u2010derived suppressor cells with C\u2010reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID\u201019
Scandinavian Journal of Immunology · 2021 SCI-Expanded
PROFESÖR UĞUR ARSLAN →
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Scandinavian Journal of Immunology · 2022 SCI-Expanded
PROFESÖR FİKRET KANAT →
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Scandinavian Journal of Immunology · 2021 SCI-Expanded
PROFESÖR FİKRET KANAT →
Correlation of myeloid\u2010derived suppressor cells with C\u2010reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID\u201019
Scandinavian Journal of Immunology · 2021 SCI-Expanded
PROFESÖR FİKRET KANAT →
Correlation of myeloid derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Scandinavian Journal of Immunology · 2022 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19.
Scandinavian Journal of Immunology · 2022 SCI-Expanded
PROFESÖR ŞUA SÜMER →
Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19
Scandinavian Journal of Immunology · 2022 SCI-Expanded
PROFESÖR HASİBE ARTAÇ →
Correlation of myeloid‐derived suppressor cells with C‐reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID‐19
Scandinavian journal of immunology · 2022 SCI-Expanded
PROFESÖR YAVUZ KÖKSAL →
Makale Bilgileri
DergiScandinavian Journal of Immunology
Yayın TarihiOcak 2022
Cilt / Sayfa95
Scopus ID2-s2.0-85117029030
Erişim🔓 Açık Erişim
Özet
The novel coronavirus disease 2019 (COVID-19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid-derived suppressor cells (MDSCs) in COVID-19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID-19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings—aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C-reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty-one patients with COVID-19 (26 mild and 15 severe; mean age of 49.7 ± 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets—polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs—by flow cytometric immunophenotyping, and PMN-MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID-19. Total MDSCs, PMN-MDSCs, mature PMN-MDSCs and monocytic MDSCs were significantly higher in patients with COVID-19 compared with the healthy controls (P <.05). Only PMN-MDSCs and their immature PMN-MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C-reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID-19. These findings suggest that MDSCs play a role in the pathogenesis of COVID-19, while PMN-MDSCs, especially immature PMN-MDSCs, are associated with the severity of the disease.
Yazarlar (10)
1
Ayca Emsen
ORCID: 0000-0003-3028-3112
2
Şua Sümer
3
Baykal Tulek
4
Hilal Cizmecioglu
5
Hüsamettin Vatansev
6
Mevlut Hakan Goktepe
7
F. Kanat
8
Yavuz Koksal
9
Ugur Arslan
10
Hasibe Artac
Anahtar Kelimeler
COVID-19
MDSC subsets and acute-phase reactants
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
7
Atıf
10
Yazar
2
Anahtar Kelime