Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · Ocak 2022
YÖKSİS Kayıtları
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
Prof. Dr. HASİBE ARTAÇ →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2022 SCI-Expanded
Prof. Dr. HANDE KÖKSAL →
The role of CD8+ regulatory T cells and B cell subsets in patients
with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
Prof. Dr. ONUR URAL →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
Doç. Dr. HÜLYA ÖZDEMİR →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
TURKISH JOURNAL OF MEDICAL SCIENCES · 2022 SCI-Expanded
Doç. Dr. DİLEK ERGÜN →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2022 SCI-Expanded
Prof. Dr. UĞUR ARSLAN →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
TURKISH JOURNAL OF MEDICAL SCIENCES · 2022 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 48 week response of treatment naive chronic hepatitis B patients to 0 5 mg day entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. ŞUA SÜMER →
Serum Interleukin 8 Levels May Predict Relapse In Brucellosis
2012 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Evaluation of 48 week Response of Treatment Naive Chronic Hepatitis B Patients to 0 5 mg day Entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
The efficacy of intermittant low dose systemic corticosteroid in the treatment of alopecia areata
2004 ISSN: 1300-0144 SCI-Expanded 1 atıf
Prof. Dr. GÜLCAN SAYLAM KURTİPEK →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. HASAN KARA →
Analysis of periprocedural medical complications during carotid angioplasty and stent placement
2010 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
High risk febrile neutropenia and its management in childrenwith solid tumors and lymphoma
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. YAVUZ KÖKSAL →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
Effectiveness of pelvic floor muscle training on symptoms and uroflowmetryparameters in female patients with overactive bladder
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. EVRİM ÇAKMAKÇI →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. NİLSEL OKUDAN →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Refeeding hypophosphatemia a potentially fatal danger in the intensive care unit
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. AYŞEGÜL BAYIR →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Hypo and hypervolemic edema in children with steroid sensitive nephrotic syndrome
2015 ISSN: 13000144 SCI-Expanded Q3
Dr. Öğr. Üyesi MEHMET AKİF BÜYÜKAVCI →
Evaluation of dental technician’s pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings
2017 ISSN: 13000144 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
Cytokeratin 18 and h FABP levels in intestinal ischemia reperfusioninjury role of coenzyme Q10
2013 ISSN: 1300-0144 SSCI 2 atıf
Prof. Dr. NİLSEL OKUDAN →
N terminal pro brain natriuretic peptide levels in children with allergic rhinitis
2016 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2022
Cilt / Sayfa52 · 888-898
Scopus ID2-s2.0-85136788631
Erişim🔓 Açık Erişim
Özet
Background/aim: Coronavirus disease 2019 (COVID-19) has a wide clinical spectrum from asymptomatic to mild, moderate, and severe cases. There are still many unknowns about the role of immunoregulatory mechanisms in COVID-19. We aimed to study regulatory T cells (Tregs) and B cell subsets and evaluate their correlations with severity of COVID-19. Materials and methods: In total, 50 patients with COVID-19 confirmed by PCR (mean age = 49.9 ± 12.8 years) and 40 healthy control (mean age = 47.9 ± 14.7 years) were included in this study. The patients were classified as 14 mild (median age = 35.5 [24–73] years), 22 moderate (median age = 51.5 [28–67] years) and 14 severe (median age = 55.5 [42–67] years). Within 24 h of admission, flow cytometry was used to assess the lymphocyte subsets, Tregs and Bregs without receiving any relevant medication. Results: In all patients with COVID-19, the proportion of CD3+CD8+ T cells was reduced (p = 0.004) and the CD8+ Tregs were increased compared with control (p = 0.001). While the levels of regulatory B cells, plasmablasts, and mature naive B cells were found to be significantly high, primarily memory B-cell levels were low in all patients compared with controls (p < 0.05). Total CD3+ T cells were negatively correlated with the length of stay in the hospital (r = –0.286, p = 0.044). Conclusion: The changes in T and B cell subsets may show the dysregulation in the immunity of patients with COVID-19. In this context, the association between CD8+ Tregs and COVID-19 severity may help clinicians to predict severe and fatal COVID-19 in hospitalized patients.
Yazarlar (7)
1
Hülya Uçaryilmaz
2
Dilek Ergün
3
Hüsamettin Vatansev
4
H. Koksal
5
Onur Ural
6
Ugur Arslan
7
Hasibe Artac
Anahtar Kelimeler
COVID-19
regulatory B cells
regulatory T cells
SARS-CoV-2
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
3
Atıf
7
Yazar
4
Anahtar Kelime