Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The role of CD8<sup>+</sup> regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · Ocak 2022
YÖKSİS Kayıtları
The role of CD8+ regulatory T cells and B cell subsets in patients
with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
PROFESÖR ONUR URAL →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
DOÇENT HÜLYA ÖZDEMİR →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
TURKISH JOURNAL OF MEDICAL SCIENCES · 2022 SCI-Expanded
DOÇENT DİLEK ERGÜN →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2022 SCI-Expanded
PROFESÖR UĞUR ARSLAN →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
TURKISH JOURNAL OF MEDICAL SCIENCES · 2022 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
Turkish Journal of Medical Sciences · 2022 SCI-Expanded
PROFESÖR HASİBE ARTAÇ →
The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2022 SCI-Expanded
PROFESÖR HANDE KÖKSAL →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2022
Cilt / Sayfa52 · 888-898
Scopus ID2-s2.0-85136788631
Erişim🔓 Açık Erişim
Özet
Background/aim: Coronavirus disease 2019 (COVID-19) has a wide clinical spectrum from asymptomatic to mild, moderate, and severe cases. There are still many unknowns about the role of immunoregulatory mechanisms in COVID-19. We aimed to study regulatory T cells (Tregs) and B cell subsets and evaluate their correlations with severity of COVID-19. Materials and methods: In total, 50 patients with COVID-19 confirmed by PCR (mean age = 49.9 ± 12.8 years) and 40 healthy control (mean age = 47.9 ± 14.7 years) were included in this study. The patients were classified as 14 mild (median age = 35.5 [24–73] years), 22 moderate (median age = 51.5 [28–67] years) and 14 severe (median age = 55.5 [42–67] years). Within 24 h of admission, flow cytometry was used to assess the lymphocyte subsets, Tregs and Bregs without receiving any relevant medication. Results: In all patients with COVID-19, the proportion of CD3+CD8+ T cells was reduced (p = 0.004) and the CD8+ Tregs were increased compared with control (p = 0.001). While the levels of regulatory B cells, plasmablasts, and mature naive B cells were found to be significantly high, primarily memory B-cell levels were low in all patients compared with controls (p < 0.05). Total CD3+ T cells were negatively correlated with the length of stay in the hospital (r = –0.286, p = 0.044). Conclusion: The changes in T and B cell subsets may show the dysregulation in the immunity of patients with COVID-19. In this context, the association between CD8+ Tregs and COVID-19 severity may help clinicians to predict severe and fatal COVID-19 in hospitalized patients.
Yazarlar (7)
1
Hülya Uçaryilmaz
2
Dilek Ergün
3
Hüsamettin Vatansev
4
H. Koksal
5
Onur Ural
6
Ugur Arslan
7
Hasibe Artac
Anahtar Kelimeler
COVID-19
regulatory B cells
regulatory T cells
SARS-CoV-2
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
2
Atıf
7
Yazar
4
Anahtar Kelime