Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
Turkish Journal of Biochemistry · Şubat 2023
YÖKSİS Kayıtları
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI · 2023 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY · 2023 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
Turk J Biochem · 2023 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY · 2023 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiŞubat 2023
Cilt / Sayfa48 · 96-103
Scopus ID2-s2.0-85152055698
Erişim🔓 Açık Erişim
Özet
Objectives: Our aim was to compare the cytotoxic effects of tamoxifen and docetaxel, currently used in breast cancer treatment, and ukrain, which demonstrates antiproliferative properties on breast cancer cells. Methods: MCF-7 and MDA MB-231 cells were treated with various doses of docetaxel, tamoxifen, and ukrain. The cytotoxic effects of all drugs were determined with the cell empedance technique. Cell blocks were prepared from cultured and drug-exposed cells for histopathological and immunohistochemical determinations of Ki-67, Bcl-2, Bax, and Cyclin-D1 expressions. Results: According to comparisons of proapoptotic and antiapoptotic protein expression indices, no statistically significant difference was found between the effects of ukrain and docetaxel in both cell lines. Although tamoxifen was more effective than ukrain in MCF-7 cells, ukrain was also more effective than tamoxifen in MDA MB-231 cells for inducing apoptosis. Conclusions: Although ukrain presented antiproliferative and apoptotic effects on both cell lines, MDA MB-231 cells were more vulnerable to the effects of ukrain. The findings suggest that ukrain might be a useful therapeutic agent, especially for treating receptor-negative breast cancer cells.
Yazarlar (5)
1
Gulsum Abusoglu
2
Cengiz Kocak
ORCID: 0000-0003-3819-6822
3
Fatma Emel Kocak
ORCID: 0000-0001-5549-3883
4
Bahadır Öztürk
5
Hüsamettin Vatansev
Anahtar Kelimeler
apoptosis
cell viability
docetaxel
MCF-7
MDA MB-231
tamoxifen
ukrain
Kurumlar
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Usak University
Usak Turkey