Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
Turkish Journal of Biochemistry · Şubat 2023
YÖKSİS Kayıtları
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI · 2023 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY · 2023 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
Turk J Biochem · 2023 SCI-Expanded
Doç. Dr. GÜLSÜM ABUŞOĞLU →
Comparison with molecular effects of ukrain, tamoxifen, and docetaxel on human breast cancer cell lines
TURKISH JOURNAL OF BIOCHEMISTRY · 2023 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Is median value of Double Screening Test regional?
2015 ISSN: 0250-4685 SCI-Expanded Q4
Doç. Dr. RAMAZAN KOCABAŞ →
Calculation of measurement uncertainty of biochemical parameters
2015 ISSN: 02504685 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
The effects of grape seed extract against toxicity of benzene on liver and kidney tissues of albino mice biochemical evaluation
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Analysis of trace elements in epileptic patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
Serum Paraoxonase Levels and Oxidative Stress in Patients with Scleroderma
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Analysis of Trace Elements in Epileptic Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
The Analytical Performance of The C Petide and Insuline Test
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Procalcitonin Levels in Inflammatory Disease
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Comparison of Routine Biochemical and Hormonal Values of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Comparison Of MPV WBC and Neutrophil Lymphocyte Ratio of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSEYİN YILMAZ →
Influence of Pinealectomy on Hemogram Parameters of Rats Applied to Sepsis Model
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Meme Kanser Hücrelerinin Fluıdıgm Dynamıc Array Kullanılarak Kantitatif miRNA Ekspresyaon Analizi
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
25 OH D3 ve 1 25 OH 2 D3 ün MCF 7 Meme Kanser Hücre Hattının Proliferasyonu Üzerine Kıyaslanması
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
The effect of single dose administration of nandrolone decanoate on plasma irisin adropin leptin levelsTek doz nandrolon dekonat uygulamasının plazma irisin adropin leptin düzeylerine etkisi
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. SEYFULLAH HALİLOĞLU →
Makale Bilgileri
ISSN02504685
Yayın TarihiŞubat 2023
Cilt / Sayfa48 · 96-103
Scopus ID2-s2.0-85152055698
Erişim🔓 Açık Erişim
Özet
Objectives: Our aim was to compare the cytotoxic effects of tamoxifen and docetaxel, currently used in breast cancer treatment, and ukrain, which demonstrates antiproliferative properties on breast cancer cells. Methods: MCF-7 and MDA MB-231 cells were treated with various doses of docetaxel, tamoxifen, and ukrain. The cytotoxic effects of all drugs were determined with the cell empedance technique. Cell blocks were prepared from cultured and drug-exposed cells for histopathological and immunohistochemical determinations of Ki-67, Bcl-2, Bax, and Cyclin-D1 expressions. Results: According to comparisons of proapoptotic and antiapoptotic protein expression indices, no statistically significant difference was found between the effects of ukrain and docetaxel in both cell lines. Although tamoxifen was more effective than ukrain in MCF-7 cells, ukrain was also more effective than tamoxifen in MDA MB-231 cells for inducing apoptosis. Conclusions: Although ukrain presented antiproliferative and apoptotic effects on both cell lines, MDA MB-231 cells were more vulnerable to the effects of ukrain. The findings suggest that ukrain might be a useful therapeutic agent, especially for treating receptor-negative breast cancer cells.
Yazarlar (5)
1
Gulsum Abusoglu
2
Cengiz Kocak
ORCID: 0000-0003-3819-6822
3
Fatma Emel Kocak
ORCID: 0000-0001-5549-3883
4
Bahadır Öztürk
5
Hüsamettin Vatansev
Anahtar Kelimeler
apoptosis
cell viability
docetaxel
MCF-7
MDA MB-231
tamoxifen
ukrain
Kurumlar
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Usak University
Usak Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Biochemistry
Q3
OA
SJR Skoru0,232
H-Index26
YayıncıWalter de Gruyter GmbH
ÜlkeGermany
Biochemistry (medical) (Q3)
Biochemistry (Q4)
Clinical Biochemistry (Q4)
Molecular Biology (Q4)
Metrikler
1
Atıf
5
Yazar
7
Anahtar Kelime