Scopus
YÖKSİS Eşleşti
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases
Metabolic Syndrome and Related Disorders · Eylül 2024
YÖKSİS Kayıtları
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases
Metabolic Syndrome and Related Disorders · 2024 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Makale Bilgileri
DergiMetabolic Syndrome and Related Disorders
Yayın TarihiEylül 2024
Cilt / Sayfa22 · 487-493
Scopus ID2-s2.0-85191575271
Özet
The endoplasmic reticulum (ER), the center of protein folding, also controls the cell’s life-and-death signaling mechanisms. ER stress caused by unfolded or misfolded proteins leads to the activation of the unfolded protein response (UPR) in the cell. The UPR utilizes three main signaling pathways to restore disrupted ER homeostasis. These signaling pathways are protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1, and activating transcription factor 6. Studies have reported that ER stress (ERS) plays a role in the pathogenesis of metabolic disorders such as diabetes, obesity, atherosclerosis, and nonalcoholic liver disease. This review will briefly discuss the ERS response in these metabolic diseases.
Yazarlar (3)
1
Firdevs Sak
2
Fatma Sengul
ORCID: 0000-0002-7097-6266
3
Hüsamettin Vatansev
Anahtar Kelimeler
central obesity
insulin resistance
NAFLD
type 2 diabetes
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of Adiyaman
Adiyaman Turkey
Metrikler
1
Atıf
3
Yazar
4
Anahtar Kelime