Scopus
YÖKSİS Eşleşti
Solubilizing effect of the p-phosphonate calix[n]arenes towards poorly soluble drug molecules such as nifedipine, niclosamide and furosemide
Journal of Inclusion Phenomena and Macrocyclic Chemistry · Ocak 2012
YÖKSİS Kayıtları
Solubilizing effect of the p phosphonate calix n arenes towards poorly soluble drug molecules such as nifedipine niclosamide and furosemide
Journal of Inclusion Phenomena and Macrocyclic Chemistry · 2012 SCI-Expanded 10 atıf
PROFESÖR ŞEREF ERTUL →
Solubilizing effect of the p phosphonate calix n arenes towards poorly soluble drug molecules such as nifedipine niclosamide and furosemide
Journal of Inclusion Phenomena and Macrocyclic Chemistry · 2012 SSCI 1 atıf
PROFESÖR MUSTAFA YILMAZ →
Makale Bilgileri
DergiJournal of Inclusion Phenomena and Macrocyclic Chemistry
Yayın TarihiOcak 2012
Cilt / Sayfa74 · 415-423
Scopus ID2-s2.0-84864440406
Özet
This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of drug molecules was significantly increased in the presence of calix[n]arene host molecules. The increase in solubility of drugs by the calix[n]arene was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug:cyclodextrin complexes. © 2012 Springer Science+Business Media B.V.
Yazarlar (3)
1
Mevlut Bayrakci
2
Seref Ertul
3
Mustafa Yilmaz
Anahtar Kelimeler
Calixarene
Drug
Furosemide
Niclosamide
Nifedipine
Kurumlar
Niğde Ömer Halisdemir University
Nigde Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
22
Atıf
3
Yazar
5
Anahtar Kelime