Phase solubility studies of poorly soluble drug molecules by using O -phosphorylated calixarenes as drug-solubilizing agents

Journal of Chemical and Engineering Data · Ocak 2012

YÖKSİS Kayıtları

Phase Solubility Studies of Poorly Soluble Drug Molecules by Using Phosphorylated Calixarenes as Drug Solubilizing Agents

Journal of Chemical & Engineering Data · 2012 SCI-Expanded 10 atıf

Prof. Dr. ŞEREF ERTUL →

YÖKSİS Kayıtları — ISSN Eşleşmesi

Phase Solubility Studies of Poorly Soluble Drug Molecules by Using Phosphorylated Calixarenes as Drug Solubilizing Agents

2012 ISSN: 0021-9568 SCI-Expanded 10 atıf

Prof. Dr. ŞEREF ERTUL →

10.1021/je200992c

Transportation of Poorly Soluble Drug Molecules from the Organic Phase to the Aqueous Phase by Using Phosphorylated Calixarenes

2011 ISSN: 0021-9568 SCI-Expanded 12 atıf

Prof. Dr. ŞEREF ERTUL →

10.1021/je2004319

Magnetizing Calixarene: Azo Dye Removal from Aqueous Media by Fe3O4 Nanoparticles Fabricated with Carboxylic-Substituted Calix[4]arene

2018 ISSN: 0021-9568 SCI

Prof. Dr. MUSTAFA YILMAZ →

Thermodynamic and Kinetic Studies for Adsorption of Reactive Blue (RB-19) Dye Using Calix[4]arene-Based Adsorbent

2019 ISSN: 0021-9568 SCI-Expanded

Dr. Öğr. Üyesi FATİH DURMAZ →

10.1021/acs.jced.9b00223

Magnetizing Calixarene: Azo Dye Removal from Aqueous Media by Fe sub3/sub O sub4/sub Nanoparticles Fabricated with Carboxylic-Substituted Calix[4]arene/title

2017 ISSN: 0021-9568 SCI-Expanded Q3

Doç. Dr. MEHMET OĞUZ →

Makale Bilgileri

Dergi Journal of Chemical and Engineering Data

ISSN00219568

Yayın TarihiOcak 2012

Cilt / Sayfa57 · 233-239

DOI10.1021/je200992c

Scopus ID2-s2.0-84855884430

Özet This study is the first report on the solubilizing effect of O-phosphorylated calix[n]arenes that form complexes with neutral molecules such as nifedipine, niclosamide, and furosemide by host-guest complexation. These complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of guest molecules such as nifedipine, niclosamide, and furosemide was significantly increased in the presence of host molecules tetrakis-O-(diethoxyphosphoryl)-p- tert-butylcalix[4]arene (1), tetrakis-O-(diethoxyphosphoryl)-calix[4]arene (2), bis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (3), bis-O- (diethoxyphosphoryl)-calix[4]arene (4), and octakis-O-(diethoxyphosphoryl)-p- tert-butylcalix[8]arene (5). The increase in solubility of drugs by the calixarene host 1 to 5 was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug-cyclodextrin complexes. © 2011 American Chemical Society.