Scopus
YÖKSİS Eşleşti
Calixarene nanofiber design for human colon cancer 3D-cell culture
Proceedings of the 2017 IEEE 7th International Conference on Nanomaterials: Applications and Properties, NAP 2017 · Aralık 2017
YÖKSİS Kayıtları
Calixarene nanofiber design for human colon cancer 3D-cell culture
Institute of Electrical and Electronics Engineers Xplore · 2017 Scopus
ÖĞRETİM GÖREVLİSİ FATİH ÖZCAN →
Calixarene nanofiber design for human colon cancer 3D-cell culture
Institute of Electrical and Electronics Engineers Xplore · 2017 Scopus
DOKTOR ÖĞRETİM ÜYESİ PEMBEGÜL UYAR ARPACI →
Makale Bilgileri
DergiProceedings of the 2017 IEEE 7th International Conference on Nanomaterials: Applications and Properties, NAP 2017
Yayın TarihiAralık 2017
Cilt / Sayfa2017-January
Scopus ID2-s2.0-85046149341
Özet
A growing body of evidence has suggested that 3D cell culture systems, in contrast to the 2D systems, represent more accurately the actual microenvironment where cells reside in tissues. Therefore, researchers have concentrated on developing realistic and sophisticated in-vitro 3D cell culture models that actually resemble the complex environment of native tissues. Calixarenes, similar to a ring basket, represent a third generation of supramolecular hosts could be promising candidates in this regard. Due to having a cyclic structure and large surface area, calixarenes, can be functionalized easily with polar and apolar groups, be a good carrier for cations, anions and neutral molecules. Electrospinning of p-tert-butylcalix[4]arene nanofibers with different functional groups were performed and their endothelial (Caco-2) and fibroblastic (L-929) cytocompatibility behaviour on cell adhesion function were examined. Cell attachment kinetics revealed that the Caco-2 and L-929 attached to the nanofibers functionalized with pyridinum at position 3 at the same rate as to tissue culture plates. In this report, for the first time in literature, it was shown that 3D cultured systems designed with calixarene nanofibers provide excellent in vitro models, allowing the study of cellular responses in a setting that resembles in vivo environments.
Yazarlar (4)
1
Pembegul Uyar Arpaci
2
Fatih Ozcan
3
M. Agaç
4
Seref Ertul
Anahtar Kelimeler
3D-Cell Culture
Calixarene
Electrospinning
Nanofiber
Surface Funtionalization
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
4
Yazar
5
Anahtar Kelime