Improved anticancer efficacy of p-tert-butylcalix[4]arene through surface modifications

Proceedings of the 2017 IEEE 7th International Conference on Nanomaterials: Applications and Properties, NAP 2017 · Aralık 2017

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Institute of Electrical and Electronics Engineers Xplore · 2017 Scopus

ÖĞRETİM GÖREVLİSİ FATİH ÖZCAN →

Improved anticancer efficacy of p-tert-butylcalix[4]arene through surface modifications

Institute of Electrical and Electronics Engineers Xplore · 2017 Scopus

DOKTOR ÖĞRETİM ÜYESİ PEMBEGÜL UYAR ARPACI →

Makale Bilgileri

DergiProceedings of the 2017 IEEE 7th International Conference on Nanomaterials: Applications and Properties, NAP 2017

Yayın TarihiAralık 2017

Cilt / Sayfa2017-January

DOI10.1109/NAP.2017.8190338

Scopus ID2-s2.0-85046282152

Özet The search for new potent anticancer drugs that can only target cancer cells, rather than affecting normal tissues is very much commendable. Supramolecular Calixarene (p-tert-butylcalix[4]arene) is a highly promising candidate in this regard and could be modified to enhance preferential cytotoxicity for targeted therapy. Calixarenes are a family of bowl or cone shaped synthetic supramolecular macrocycles, composed of phenol units linked by methylene bridges through and an aldehyde. The proliferation rate of L-929 were observed higher than MCF-7 cells in the Real-Time Cell Analysis (RTCA) Systems. Our research directs that calixarene shows effective preferential cytotoxicity at a concentration range of 25 to 100 μg/mL with enhanced preferential cytotoxicity shown by the modification of pyridinium group at the position 3 against MCF-7 breast cancer cells. In this present study, the effect of surface altered calixarene by pyridinium groups on preferential cytotoxicity in cancer cell in-vitro by comparing with innate preferential toxicity shown by unaltered. The results reported in this study demonstrated that tumor-preferential in-vitro cytotoxicity of p-tert-butylcalix[4]arene against MCF-7 over L-929 cells present a promising approach for efficient and safe cancer therapy.