Scopus
YÖKSİS Eşleşti
Determination of tear and serum inflammatory cytokines in patients with rosacea using multiplex bead technology
Ocular Immunology and Inflammation · Ekim 2013
YÖKSİS Kayıtları
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
Ocular Immunology and Inflammation · 2013 SCI
PROFESÖR BANU BOZKURT →
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
Ocular Immunology and Inflammation · 2013 SCI-Expanded
PROFESÖR BANU BOZKURT →
Makale Bilgileri
DergiOcular Immunology and Inflammation
Yayın TarihiEkim 2013
Cilt / Sayfa21 · 351-359
Scopus ID2-s2.0-84885655708
Özet
Purpose: To compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and evaluate the correlation of tear cytokine levels with tear function parameters. Methods: Tear and serum interleukin (IL)-1α, IL-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) levels were measured using multiplex bead (Luminex) technology in 12 rosacea patients without ocular involvement (group 1), 20 rosacea patients with ocular involvement (group 2), and 22 healthy subjects (group 3). The correlation of the cytokines with tear function parameters was analyzed using Spearman correlation test. Results: Tear IL-10 and VEGF levels were significantly lower in group 1 (median: 35.78pg/mL and 427.29, respectively) and group 2 (median: 26.25pg/mL and 348.31, respectively) than in group 3 (median: 75.96pg/mL and 480.12, respectively) (p<0.05). Mean serum IL-8 level was significantly lower in group 2 (median=0) compared to group 3 (median=3.98) (p=0.02). Tear breakup time was found to be positively correlated with IL-10 (r=0.46, p=0.013) and inversely correlated with MCP-1 (r=-0.52, p=0.004). Conclusions: Tear and serum levels of cytokines and growth factors measured with Luminex technology showed a large variation in rosacea and healthy subjects. Decreased levels of tear IL-10, an anti-inflammatory cytokine, may lead to an inflammatory ocular surface environment, exacerbate ocular surface inflammation, and deteriorate tear function tests. A bigger sample size, including rosacea patients with corneal involvement, is needed to confirm the role of cytokines in the pathogenesis of rosacea-associated ocular inflammation. © 2013 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
Yazarlar (7)
1
Pinar Topcu-Yilmaz
2
Nilgun Atakan
3
Banu Bozkurt
ORCID: 0000-0002-9847-3521
4
M. İrkeç
5
Demet Aban
6
Lutfiye Mesci
7
Ilhan Tezcan
Anahtar Kelimeler
Cytokine
Interleukin
Luminex technology
Rosacea
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
21
Atıf
7
Yazar
4
Anahtar Kelime