Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Determination of tear and serum inflammatory cytokines in patients with rosacea using multiplex bead technology
Ocular Immunology and Inflammation · Ekim 2013
YÖKSİS Kayıtları
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
Ocular Immunology and Inflammation · 2013 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
Ocular Immunology and Inflammation · 2013 SCI
Prof. Dr. BANU BOZKURT →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Quantitative Assessment of Anterior Chamber Inflammation in Patients with Retained Presumed Intraocular Cotton Fiber after Phacoemulsification
2013 ISSN: 0927-3948 SCI
Prof. Dr. ŞABAN GÖNÜL →
Quantitative Assessment of Anterior Chamber Inflammation in Patients with Retained Presumed Intraocular Cotton Fiber After phacoemulsification
2013 ISSN: 0927-3948 SSCI
Prof. Dr. ŞABAN GÖNÜL →
Quantitative assessment of anterior chamber inflammation in patients with retained presumed intraocular cotton fiber after phacoemulsification
2013 ISSN: 0927-3948 SCI-Expanded
Prof. Dr. ŞABAN GÖNÜL →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2016 ISSN: 0927-3948 SCI
Prof. Dr. ALİ ÜNLÜ →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2016 ISSN: 0927-3948 SCI
Prof. Dr. BANU BOZKURT →
Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis
2013 ISSN: 0927-3948 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2016 ISSN: 0927-3948 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2018 ISSN: 0927-3948 SCI-Expanded
Doç. Dr. HÜLYA ÖZDEMİR →
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
2013 ISSN: 0927-3948 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2018 ISSN: 0927-3948 SCI
Prof. Dr. ALİ ÜNLÜ →
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis
2018 ISSN: 0927-3948 SSCI
Prof. Dr. METE KAAN BOZKURT →
Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report
2022 ISSN: 0927-3948 SCI Q2
Prof. Dr. ŞABAN GÖNÜL →
Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis
2013 ISSN: 0927-3948 SCI
Prof. Dr. HASİBE ARTAÇ →
Unilateral Acute Iris Transillumination Syndrome following Uneventful Phacoemulsification Surgery with Intracameral Moxifloxacin
2021 ISSN: 0927-3948 SCI-Expanded Q2
Prof. Dr. ŞABAN GÖNÜL →
Bilateral Retinal Venous Occlusion in Atypical Hemolytic-Uremic Syndrome Due to Complement Factor H Mutation
2024 ISSN: 0927-3948 SCI-Expanded Q2
Öğr. Gör. SERHAT EKER →
Bilateral Retinal Venous Occlusion in Atypical Hemolytic-Uremic Syndrome Due to Complement Factor H Mutation
2024 ISSN: 0927-3948 SCI-Expanded Q2
Prof. Dr. ŞABAN GÖNÜL →
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology
2013 ISSN: 0927-3948 SCI
Prof. Dr. BANU BOZKURT →
Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis
2013 ISSN: 0927-3948 SCI
Prof. Dr. BANU BOZKURT →
Makale Bilgileri
ISSN09273948
Yayın TarihiEkim 2013
Cilt / Sayfa21 · 351-359
Scopus ID2-s2.0-84885655708
Özet
Purpose: To compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and evaluate the correlation of tear cytokine levels with tear function parameters. Methods: Tear and serum interleukin (IL)-1α, IL-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) levels were measured using multiplex bead (Luminex) technology in 12 rosacea patients without ocular involvement (group 1), 20 rosacea patients with ocular involvement (group 2), and 22 healthy subjects (group 3). The correlation of the cytokines with tear function parameters was analyzed using Spearman correlation test. Results: Tear IL-10 and VEGF levels were significantly lower in group 1 (median: 35.78pg/mL and 427.29, respectively) and group 2 (median: 26.25pg/mL and 348.31, respectively) than in group 3 (median: 75.96pg/mL and 480.12, respectively) (p<0.05). Mean serum IL-8 level was significantly lower in group 2 (median=0) compared to group 3 (median=3.98) (p=0.02). Tear breakup time was found to be positively correlated with IL-10 (r=0.46, p=0.013) and inversely correlated with MCP-1 (r=-0.52, p=0.004). Conclusions: Tear and serum levels of cytokines and growth factors measured with Luminex technology showed a large variation in rosacea and healthy subjects. Decreased levels of tear IL-10, an anti-inflammatory cytokine, may lead to an inflammatory ocular surface environment, exacerbate ocular surface inflammation, and deteriorate tear function tests. A bigger sample size, including rosacea patients with corneal involvement, is needed to confirm the role of cytokines in the pathogenesis of rosacea-associated ocular inflammation. © 2013 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
Yazarlar (7)
1
Pinar Topcu-Yilmaz
2
Nilgun Atakan
3
Banu Bozkurt
ORCID: 0000-0002-9847-3521
4
M. İrkeç
5
Demet Aban
6
Lutfiye Mesci
7
Ilhan Tezcan
Anahtar Kelimeler
Cytokine
Interleukin
Luminex technology
Rosacea
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Ocular Immunology and Inflammation
Q2
SJR Skoru0,724
H-Index75
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Ophthalmology (Q2)
Immunology and Allergy (Q3)
Metrikler
25
Atıf
7
Yazar
4
Anahtar Kelime