Scopus
🔓 Açık Erişim
Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis
The Lancet Global Health · Aralık 2017
Makale Bilgileri
DergiThe Lancet Global Health
Yayın TarihiAralık 2017
Cilt / Sayfa5 · e1221-e1234
Scopus ID2-s2.0-85031280854
Erişim🔓 Açık Erişim
Özet
Background Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. Methods In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014. We identified population-based studies published before July 8, 2014, by searching online databases with no language restrictions (MEDLINE from Jan 1, 1946, and Embase from Jan 1, 1974, and the WHO Library Database). We fitted a series of regression models to estimate the proportion of moderate or severe vision impairment (defined as presenting visual acuity of <6/18 but ≥3/60 in the better eye) and blindness (presenting visual acuity of <3/60 in the better eye) by cause, age, region, and year. Findings We identified 288 studies of 3 983 541 participants contributing data from 98 countries. Among the global population with moderate or severe vision impairment in 2015 (216·6 million [80% uncertainty interval 98·5 million to 359·1 million]), the leading causes were uncorrected refractive error (116·3 million [49·4 million to 202·1 million]), cataract (52·6 million [18·2 million to 109·6 million]), age-related macular degeneration (8·4 million [0·9 million to 29·5 million]), glaucoma (4·0 million [0·6 million to 13·3 million]), and diabetic retinopathy (2·6 million [0·2 million to 9·9 million]). Among the global population who were blind in 2015 (36·0 million [12·9 million to 65·4 million]), the leading causes were cataract (12·6 million [3·4 million to 28·7 million]), uncorrected refractive error (7·4 million [2·4 million to 14·8 million]), and glaucoma (2·9 million [0·4 million to 9·9 million]). By 2020, among the global population with moderate or severe vision impairment (237·1 million [101·5 million to 399·0 million]), the number of people affected by uncorrected refractive error is anticipated to rise to 127·7 million (51·0 million to 225·3 million), by cataract to 57·1 million (17·9 million to 124·1 million), by age-related macular degeneration to 8·8 million (0·8 million to 32·1 million), by glaucoma to 4·5 million (0·5 million to 15·4 million), and by diabetic retinopathy to 3·2 million (0·2 million to 12·9 million). By 2020, among the global population who are blind (38·5 million [13·2 million to 70·9 million]), the number of patients blind because of cataract is anticipated to rise to 13·4 million (3·3 million to 31·6 million), because of uncorrected refractive error to 8·0 million (2·5 million to 16·3 million), and because of glaucoma to 3·2 million (0·4 million to 11·0 million). Cataract and uncorrected refractive error combined contributed to 55% of blindness and 77% of vision impairment in adults aged 50 years and older in 2015. World regions varied markedly in the causes of blindness and vision impairment in this age group, with a low prevalence of cataract (<22% for blindness and 14·1–15·9% for vision impairment) and a high prevalence of age-related macular degeneration (>14% of blindness) as causes in the high-income subregions. Blindness and vision impairment at all ages in 2015 due to diabetic retinopathy (odds ratio 2·52 [1·48–3·73]) and cataract (1·21 [1·17–1·25]) were more common among women than among men, whereas blindness and vision impairment due to glaucoma (0·71 [0·57–0·86]) and corneal opacity (0·54 [0·43–0·66]) were more common among men than among women, with no sex difference related to age-related macular degeneration (0·91 [0·70–1·14]). Interpretation The number of people affected by the common causes of vision loss has increased substantially as the population increases and ages. Preventable vision loss due to cataract (reversible with surgery) and refractive error (reversible with spectacle correction) continue to cause most cases of blindness and moderate or severe vision impairment in adults aged 50 years and older. A large scale-up of eye care provision to cope with the increasing numbers is needed to address avoidable vision loss. Funding Brien Holden Vision Institute.
Yazarlar (99)
1
Seth R. Flaxman
2
Rupert R.A. Bourne
3
Serge Resnikoff
4
Peter Ackland
5
Tasanee Braithwaite
6
Maria V. Cicinelli
7
Aditi Das
8
Jost B. Jonas
9
Jill Keeffe
10
John H. Kempen
11
Janet Leasher
12
Hans Limburg
13
Kovin Naidoo
14
Konrad Pesudovs
15
Alex Silvester
16
Gretchen A. Stevens
17
Nina Tahhan
18
Tien Y. Wong
19
Hugh R. Taylor
20
Aries Arditi
21
Yaniv Barkana
22
Banu Bozkurt
ORCID: 0000-0002-9847-3521
23
Alain Bron
24
Donald Budenz
25
Feng Cai
26
Robert Casson
27
Usha Chakravarthy
28
Jaewan Choi
29
Nathan Congdon
30
Reza Dana
31
Rakhi Dandona
32
Lalit Dandona
33
Iva Dekaris
34
Monte Del Monte
35
Jenny Deva
36
Laura Dreer
37
Leon Ellwein
38
Marcela Frazier
39
Kevin Frick
40
David Friedman
41
Joao Furtado
42
Hua Gao
43
Gus Gazzard
44
Ronnie George
45
Stephen Gichuhi
46
Victor Gonzalez
47
Billy Hammond
48
Mary Elizabeth Hartnett
49
Minguang He
50
James Hejtmancik
51
Flavio Hirai
52
John Huang
53
April Ingram
54
Jonathan Javitt
55
Charlotte Joslin
56
Moncef Khairallah
57
Rohit Khanna
58
Judy Kim
59
George Lambrou
60
Van Charles Lansingh
61
Paolo Lanzetta
62
Jennifer Lim
63
Kaweh Mansouri
64
Anu Mathew
65
Alan Morse
66
Beatriz Munoz
67
David Musch
68
Vinay Nangia
69
Maria Palaiou
70
Maurizio Battaglia Parodi
71
Fernando Yaacov Pena
72
Tunde Peto
73
Harry Quigley
74
Murugesan Raju
75
Pradeep Ramulu
76
Dana Reza
77
Alan Robin
78
Luca Rossetti
79
Jinan Saaddine
80
Mya Sandar
81
Janet Serle
82
Tueng Shen
83
Rajesh Shetty
84
Pamela Sieving
85
Juan Carlos Silva
86
Rita S. Sitorus
87
Dwight Stambolian
88
Jaime Tejedor
89
James Tielsch
90
Miltiadis Tsilimbaris
91
Jan van Meurs
92
Rohit Varma
93
Gianni Virgili
94
Ya Xing Wang
95
Ning Li Wang
96
Sheila West
97
Peter Wiedemann
98
Richard Wormald
99
Yingfeng Zheng
Kurumlar
Alberta Children's Hospital
Calgary Canada
Anglia Ruskin University
Cambridge United Kingdom
Beijing Tongren Hospital, Capital Medical University
Beijing China
Brien Holden Vision Institute
Sydney Australia
Capital Medical University
Beijing China
Centre Hospitalier Universitaire Dijon Bourgogne
Dijon France
Clinique de Montchoisi
Lausanne Switzerland
Eye Clinic Svjetlost
Zagreb Croatia
Fundacion Vision
Asuncion Paraguay
George Institute for International Health
Sydney Australia
Green-Valley Group
United States
HanGil Eye Hospital
Incheon South Korea
Harvard Medical School
Boston United States
Health Information Services
Grootebroek Netherlands
HelpMeSee, Inc.
New York United States
Henry Ford Hospital
Detroit United States
Hospital Universitario Ramón y Cajal
Madrid Spain
Icahn School of Medicine at Mount Sinai
New York United States
IRCCS Ospedale San Raffaele
Milan Italy
Jewish Guild Healthcare
New York United States
Johns Hopkins Bloomberg School of Public Health
Baltimore United States
Johns Hopkins University School of Medicine
Baltimore United States
Keck School of Medicine of USC
Los Angeles United States
L.V. Prasad Eye Institute India
Hyderabad India
Massachusetts Eye and Ear Institute
Boston United States
Mayo Clinic
Rochester United States
Medical College of Wisconsin
Milwaukee United States
Medical Research Foundation, Chennai
Chennai India
Melbourne School of Population and Global Health
Melbourne Australia
Moorfields Eye Hospital NHS Foundation Trust
London United Kingdom
Myungsung Christian Medical Center
Addis Ababa Ethiopia
National Center for Chronic Disease Prevention and Health Promotion
Atlanta United States
National Eye Institute (NEI)
Bethesda United States
National Institutes of Health (NIH)
Bethesda United States
National University of Singapore
Singapore City Singapore
Novartis International AG
Basel Switzerland
Nova Southeastern University
Fort Lauderdale United States
Organisation Mondiale de la Santé
Geneva Switzerland
Pan American Health Organization
Washington, D.C. United States
Queen's University Belfast
Belfast United Kingdom
Rotterdam Eye Hospital
Rotterdam Netherlands
Royal Children's Hospital, Melbourne
Melbourne Australia
Royal Liverpool University Hospital
Liverpool United Kingdom
Schepens Eye Research Institute
Boston United States
Selçuk Üniversitesi
Selçuklu Turkey
Shamir Medical Center
Beer Yacov Israel
SpaMedica Research Institute
Bolton United Kingdom
St James's University Hospital
Leeds United Kingdom
Suraj Eye Institute
Nagpur India
The College of Medicine and Public Health
Adelaide Australia
The International Agency for the Prevention of Blindness
London United Kingdom
The Johns Hopkins Hospital
Baltimore United States
The University of Adelaide
Adelaide Australia
The University of Alabama at Birmingham
Birmingham United States
The University of Utah
Salt Lake City United States
UCL Institute of Ophthalmology
London United Kingdom
Universidade de São Paulo
Sao Paulo Brazil
Universidade Federal de São Paulo
Sao Paulo Brazil
Università degli Studi di Firenze
Florence Italy
Università degli Studi di Milano
Milan Italy
Università degli Studi di Udine
Udine Italy
Universitas Indonesia
Depok Indonesia
Universität Leipzig
Leipzig Germany
Universitätsklinikum Mannheim
Mannheim Germany
Universiti Tunku Abdul Rahman
Kajang Malaysia
University Hospital of Monastir
Monastir Tunisia
University of Georgia
Athens United States
University of Illinois at Chicago
Chicago United States
University of Illinois Urbana-Champaign
Urbana United States
University of KwaZulu-Natal
Durban South Africa
University of Melbourne
Melbourne Australia
University of Miami
Coral Gables United States
University of Michigan, Ann Arbor
Ann Arbor United States
University of Missouri
Columbia United States
University of Nairobi
Nairobi Kenya
University of Oxford
Oxford United Kingdom
University of Pennsylvania
Philadelphia United States
University of Pennsylvania Perelman School of Medicine
Philadelphia United States
University of Washington
Seattle United States
UNSW Sydney
Sydney Australia
Valley Retina Institute
McAllen United States
Visibility Metrics LLC
New York United States
Wilmer Eye Institute
Baltimore United States
Yale School of Medicine
New Haven United States
Metrikler
2270
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99
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