Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · Eylül 2021
YÖKSİS Kayıtları
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · 2021 SCI-Expanded
PROFESÖR MAHMUT OK →
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · 2021 SCI-Expanded
DOÇENT MERVE İDER →
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · 2021 SCI-Expanded
DOÇENT AMİR NASERİ →
Biomarkers in premature calves with and without respiratory distress syndrome
Journal of Veterinary Internal Medicine · 2021 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Biomarkers in premature calves with and without respiratory distress syndrome
JOURNAL OF VETERINARY INTERNAL MEDICINE · 2021 SCI-Expanded
DOÇENT AMİR NASERİ →
Makale Bilgileri
DergiJournal of Veterinary Internal Medicine
Yayın TarihiEylül 2021
Cilt / Sayfa35 · 2524-2533
Scopus ID2-s2.0-85109063696
Erişim🔓 Açık Erişim
Özet
Background: Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung-specific epithelial and endothelial biomarkers are needed. Objective: To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RDS) by using lung-specific epithelial and endothelial biomarkers and determine the prognostic value of these markers in premature calves. Animals: Fifty premature calves with RDS, 20 non-RDS premature calves, and 10 healthy term calves. Methods: Hypoxia, hypercapnia, and tachypnea were considered criteria for RDS. Arterial blood gases (PaO2, PaCO2, oxygen saturation [SO2], base excess [BE], and serum lactate concentration) were measured to assess hypoxia. Serum concentrations of lung-specific growth differentiation factor-15 (GDF-15), asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and surfactant protein D (SP-D) were measured to assess PAH. Results: Arterial blood pH, PaO2, SO2, and BE of premature calves with RDS were significantly lower and PaCO2 and lactate concentrations higher compared to non-RDS premature and healthy calves. The ADMA and SP-D concentrations of premature calves with RDS were lower and serum ET-1 concentrations higher than those of non-RDS premature and healthy calves. No statistical differences for GDF-15 and VEGF were found among groups. Conclusions and Clinical Importance: Significant increases in serum ET-1 concentrations and decreases in ADMA and SP-D concentrations highlight the utility of these markers in the diagnosis of PAH in premature calves with RDS. Also, we found that ET-1 was a reliable diagnostic and prognostic biomarker for PAH and predicting mortality in premature calves.
Yazarlar (9)
1
Merve Ider
ORCID: 0000-0003-2928-5452
2
Amir Naseri
3
M. Ok
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
Alper Erturk
6
Murat Kaan Durgut
7
T. M. Parlak
8
Nimet Ismailoglu
ORCID: 0000-0003-3365-584X
9
Muhammed M. Kapar
ORCID: 0000-0002-8127-6994
Anahtar Kelimeler
endothelial biomarkers
premature calf
pulmonary epithelium
pulmonary hypertension
RDS
Kurumlar
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
9
Yazar
5
Anahtar Kelime