Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · Ocak 2023
YÖKSİS Kayıtları
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
Prof. Dr. AYŞE ER →
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Academy of Sciences Chancellery · 2023 SCI-Expanded
Prof. Dr. BURAK DİK →
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
Dr. Öğr. Üyesi TUĞBA MELİKE PARLAK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of combinations of intravenous small-volume hypertonic sodium chloride, acetate Ringer, sodium bicarbonate, and lactate Ringer solutions along with oral fluid on the treatment of calf diarrhea
2018 ISSN: 1505-1773 SCI-Expanded Q3
Doç. Dr. AMİR NASERİ →
Effect of combinations of intravenous small-volume hypertonic sodium chloride, acetate Ringer, sodium bicarbonate, and lactate Ringer solutions along with oral fluid on the treatment of calf diarrhea
2018 ISSN: 1505-1773 SCI
Prof. Dr. HASAN GÜZELBEKTEŞ →
The level of serum ionised calcium, aspartate aminotransferase, insulin, glucose, betahydroxybutyrate concentrations and blood gas parameters in cows with left displacement of abomasum
2006 ISSN: 1505-1773 SCI-Expanded
Prof. Dr. MAHMUT OK →
The evaluation of hemostatic dysfunction and disseminated intravascular coagulation in dairy cows with abomasal displacement
2018 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. MUSTAFA ARICAN →
The evaluation of hemostatic dysfunction and disseminated intravascular coagulation in dairy cows with abomasal displacement
2018 ISSN: 1505-1773 SCI-Expanded
Prof. Dr. RAMAZAN ÇÖL →
Glucose-6-phosphate dehydrogenase,glutathione peroxidase, total glutationeand reduced nicotinamide adeninedinucleotide phosphate in milk cellsof subclinical mastitic cows
2018 ISSN: 1505-1773 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis
2020 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. MAHMUT OK →
Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis
2020 ISSN: 1505-1773 SCI-Expanded Q3
Doç. Dr. MERVE İDER →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
2021 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
The clinical efficacy of pentoxifylline
and l-glutamine on ischemia and reperfusion
injury in cattle with displaced abomasum:
a longitudinal study
2021 ISSN: 1505-1773 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
2021 ISSN: 1505-1773 SCI-Expanded
Prof. Dr. MUSTAFA ARICAN →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
2021 ISSN: 1505-1773 SCI-Expanded Q2
Prof. Dr. BÜNYAMİN TRAŞ →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
2021 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. RAMAZAN ÇÖL →
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
2022 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. KAMİL ÜNEY →
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
2022 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. BURAK DİK →
Molecular cloning of the OMP19 gene from Brucella melitensis strain H38 and its antigenicity compared to that of commercial OMP19
2022 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. ZAFER SAYIN →
Molecular cloning of the OMP19 gene from Brucella melitensis strain H38 and its antigenicity compared to that of commercial OMP19
2022 ISSN: 1505-1773 SCI-Expanded Q3
Prof. Dr. OSMAN ERGANİŞ →
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
2022 ISSN: 15051773 SCI Q3
Prof. Dr. BÜNYAMİN TRAŞ →
Molecular cloning of the OMP19 gene from Brucella melitensis strain H38 and its antigenicity compared to that of commercial OMP19
2022 ISSN: 1505-1773 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep
2023 ISSN: 1505-1773 SCI-Expanded Q3
Doç. Dr. MERVE İDER →
Makale Bilgileri
ISSN15051773
Yayın TarihiOcak 2023
Cilt / Sayfa26 · 549-557
Scopus ID2-s2.0-85179637698
Özet
Cyclosporine is an immunosuppressive drug that is used to prevent tissue rejection in organ transplants and to treat autoimmune diseases such as psoriasis and rheumatoid arthritis. It has important toxic effects in many organs such as the liver and kidney. The aim of this study was to determine and compare the effectiveness of the single and combined treatment of dipyridamole, which is a vasodilator and has an antioxidant effect, ketotifen which is toll-like receptor-4 inhibitory and has an antioxidant effect, quercetin which is an antioxidant and has an anti-inflammatory effect in cyclosporine-induced hepatorenal toxicity. Forty-eight Wistar Albino rats were divided into 7 groups. The research period was 21 days. The cyclosporine increased serum ALT and AST levels, in contrast to their increased levels prevented by all the treatments. The serum creatinine level decreased significantly with ketotifen and combined treatment, while cyclosporine partially increased serum creatinine and urea levels. The urine microalbumin and protein levels were increased significantly by cyclosporine, whereas they decreased with dipyridamole treatment. The protein levels decreased by quercetin and combined treatments. The kidney injury molecule-1 and retinol-binding protein levels were increased by the cyclosporine, while ketotifen treatment partially decreased them. In conclusion, ketotifen and dipyridamole can prevent cyclosporine-induced hepatorenal toxicity and quercetin can increase the effectiveness of this treatment.
Yazarlar (5)
1
Burak Dik
2
T. M. Parlak
3
Oznur Tufan
4
F. B. Ozgur
5
A. Er
Anahtar Kelimeler
cyclosporine
dipyridamole
hepatorenal toxicity
ketotifen
quercetin
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Polish Journal of Veterinary Sciences
Q2
SJR Skoru0,348
H-Index39
YayıncıPolska Akademia Nauk
ÜlkePoland
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
4
Atıf
5
Yazar
5
Anahtar Kelime