Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Is the IL-6 -174G/C Gene Polymorphism Related to the Disease Severity Score in Turkish Children with Familial Mediterranean Fever?
Biochemical Genetics · Aralık 2016
YÖKSİS Kayıtları
Is the IL 6 174G C Gene Polymorphism Related to the Disease Severity Score in Turkish Children with Familial Mediterranean Fever
Biochemical Genetics · 2016 SCI-Expanded
Prof. Dr. RESUL YILMAZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Isolation and sequence analysis of wheat NBS LRR type disease resistance gene analogs using degenerate PCR primers
2007 ISSN: 0006-2928 SCI-Expanded
Prof. Dr. ERDOĞAN EŞREF HAKKI →
Is the IL 6 174G C Gene Polymorphism Related to the Disease Severity Score in Turkish Children with Familial Mediterranean Fever
2016 ISSN: 0006-2928 SCI-Expanded
Prof. Dr. RESUL YILMAZ →
Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc
2017 ISSN: 0006-2928 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model.
2017 ISSN: 0006-2928 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
Clinical and Demographic Evaluation According to MEFV Genes in Patients with Familial Mediterranean Fever
2019 ISSN: 0006-2928 SCI-Expanded
Prof. Dr. RESUL YILMAZ →
Assessment of Pathogenic Variants in the PAH Gene and Genotype–Phenotype Correlation in Phenylketonuria Patients from Turkey
2025 ISSN: 0006-2928 SCI-Expanded Q4
Dr. Öğr. Üyesi BANU KADIOĞLU YILMAZ →
Makale Bilgileri
Dergi
Biochemical Genetics
ISSN00062928
Yayın TarihiAralık 2016
Cilt / Sayfa54 · 886-893
Scopus ID2-s2.0-84979966586
Özet
Familial Mediterranean fever (FMF) is an autosomal recessively inherited disease characterized by recurrent self-limited attacks of fever accompanied by aseptic inflammation of serosal spaces, joints and skin, peritonitis, pleuritis, and arthritis. Clinical features differ according to genetics variants. The aim of this study was to identify relationship between IL-6 -174G/C gene polymorphisms and clinical features, disease severity score (DSS) and proteinuria in children diagnosed with FMF. In this study, 99 children who were followed-up in Gaziosmanpasa University Medical Faculty Department of Pediatrics and diagnosed with Familial Mediterranean fever according to Tel-Hashomer criteria were included. One hundred and fifty seven children who admitted to the hospital with any complain and found healthy included in control group. Genotyping was done for polymorphism in a promoter region of IL-6 gene (G/C at -174). The IL-6 -174G/C gene polymorphism and the clinical features of FMF, proteinuria, the DSS, and the healthy control group were investigated. Data for the clinical features were obtained retrospectively from the electronic records of patients. All of the genotyping of blood samples were done in Medical Genetic laboratory of Gaziosmanpasa University School of Medicine. The results revealed that the distribution of the genotypes and allele frequencies of the IL-6 -174G/C polymorphism were not significantly different between the FMF patients and the healthy controls. The IL-6 -174G/C polymorphisms did not affect proteinuria, the DSS, and the clinical features of FMF patients.
Yazarlar (5)
1
Samet Özer
ORCID: 0000-0003-0880-7215
2
Resul Yilmaz
3
Ergün Sönmezgöz
4
Şeyma Ünuvar
5
Ömer Ateş
ORCID: 0000-0003-4266-393X
Anahtar Kelimeler
Disease Severity score
Familial Mediterranean fever
Gene polymorphism
IL-6
Kurumlar
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biochemical Genetics
Q2
SJR Skoru0,544
H-Index50
YayıncıSpringer
ÜlkeUnited States
Ecology, Evolution, Behavior and Systematics (Q2)
Medicine (miscellaneous) (Q2)
Biochemistry (Q3)
Genetics (Q3)
Molecular Biology (Q3)
Metrikler
1
Atıf
5
Yazar
4
Anahtar Kelime