Scopus
YÖKSİS Eşleşti
Association between Trp64arg polymorphism of the β3 adrenoreceptor gene and female sex in Obese Turkish children and adolescents
Pediatric Gastroenterology, Hepatology and Nutrition · Ocak 2019
YÖKSİS Kayıtları
Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents
Pediatric Gastroenterology, Hepatology Nutrition · 2019 ESCI ve PubMed
PROFESÖR RESUL YILMAZ →
Makale Bilgileri
DergiPediatric Gastroenterology, Hepatology and Nutrition
Yayın TarihiOcak 2019
Cilt / Sayfa22 · 460-469
Scopus ID2-s2.0-85076555778
Özet
Purpose: The β3-adrenergic receptor (ADRB3) is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study, we aimed to investigate the association of polymorphism of the ADRB3 gene with the sex of children with obesity and related pathologies. Methods: ADRB3 gene trp64arg genotyping was conducted in 441 children aged 6-18 years. Among these subjects, 264 were obese (103 boys; 161 girls) and 179 were of normal weight (81 boys; 98 girls). In the obese group, fasting lipids, glucose and insulin levels, and blood pressure were measured. Metabolic syndrome (MS) was defined according to the modified World Health Organization criteria adapted for children. Results: The frequency of trp64arg genotype was similar in obese and normal weight children. In obese children, serum lipid, glucose, and insulin levels; homeostasis model assessment of insulin resistance (HOMA-IR) scores; and MS were not different between arg allele carriers (trp64arg) and noncarriers (trp64trp). In 264 obese children, genetic analysis results revealed that the arg allele carriers were significantly higher in girls than in boys (p=0.001). In the normal weight group, no statistically significant difference was found between genotypes of boys and girls (p=0.771). Conclusion: Trp64arg polymorphism of the ADRB3 gene was not associated with obesity and MS in Turkish children and adolescents. Although no relationships were observed between the genotypes and lipids, glucose/insulin levels, or HOMA-IR, the presence of trp64arg variant was frequent in obese girls, which can lead to weight gain as well as difficulty in losing weight in women.
Yazarlar (6)
1
Resul Yilmaz
2
Ömer Ateş
ORCID: 0000-0003-4266-393X
3
Ali Gul
4
Tuba Kasap
5
Samet Özer
ORCID: 0000-0003-0880-7215
6
Emel Ensari
ORCID: 0000-0002-6190-878X
Anahtar Kelimeler
Child
Gene polymorphism
Obesity
ß3-adrenergic receptor
Kurumlar
Memorial Hospital
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Metrikler
4
Atıf
6
Yazar
4
Anahtar Kelime