Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis
Northern Clinics of Istanbul · Ocak 2023
YÖKSİS Kayıtları
Mannose-Binding Lectin (MBL) Levels in Children with Hashimoto\u2019s Thyroiditis
Northern Clinics of Istanbul · 2023 ESCI
PROFESÖR RESUL YILMAZ →
Makale Bilgileri
DergiNorthern Clinics of Istanbul
Yayın TarihiOcak 2023
Cilt / Sayfa10 · 353-358
Scopus ID2-s2.0-85164739330
Erişim🔓 Açık Erişim
Özet
OBJECTIVE: Hashimoto’s thyroiditis (HT) was described many years ago, but the etiopathogenesis remains unclear. Man-nose-binding lectin (MBL) initiates complement activation in the lectin pathway. We determined MBL levels in children with HT and the associations thereof with thyroid hormone and thyroid autoantibody levels. METHODS: Thirty-nine patients with HT and 41 controls were enrolled from the pediatric outpatient clinics. Subjects were grouped according to their thyroid functions: Euthyroid, marked hypothyroidism and clinical/subclinical hyperthyroidism. MBL levels were compared among these groups. Serum MBL levels of the subjects were determined using MBL Human ELISA kit. RESULTS: Serum MBL levels were studied in serum samples from the 80 subjects (48 (60.0%) females). MBL levels in HT and control groups were 50.787±34.718 and 50.593±44.28 ng/ml (p=0,983), respectively. In HT group, there was no significant difference in MBL levels between thyroid function groups (p=0.869). In addition, gender was not detected as a factor for serum MBL levels. Also we found negative correlation between WBC and serum MBL levels (r=-0.532; p=0.050). Otherwise there was no correlation between TSH, anti-TPO and anti-TG with serum MBL levels. CONCLUSION: MBL levels did not decrease in HT patients. Further research is needed to elucidate more fully any role for MBL in the development of autoimmune thyroid disease.
Yazarlar (4)
1
Ali Gul
2
Nihal Hatipoglu
3
Resul Yilmaz
4
Haci Omer Ates
Anahtar Kelimeler
Autoimmune disease and hypothyroidism
children
Hashimoto’s thyroiditis
mannose binding lectin
Kurumlar
Erciyes University, Faculty of Medicine
Kayseri Turkey
Selçuk Tip Fakültesi
Konya Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Metrikler
1
Atıf
4
Yazar
4
Anahtar Kelime