Scopus
Chemical composition and biological activities of Cypriot propolis
Journal of Apicultural Research · Ocak 2022
Makale Bilgileri
DergiJournal of Apicultural Research
Yayın TarihiOcak 2022
Cilt / Sayfa61 · 233-245
Scopus ID2-s2.0-85116417655
Özet
Propolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. α-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36–11.56 µg/mL; 1.44–9.33 µg/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 µg/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 ± 0.10%) and antimicrobial activities (with a MIC value of 31.2 μg/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).
Yazarlar (12)
1
Ayşe Nalbantsoy
ORCID: 0000-0002-3852-1974
2
Nazli Boke Sarıkahya
ORCID: 0000-0002-8200-8561
3
Cenk Serhan Özverel
ORCID: 0000-0001-9932-4774
4
Ayşe Berçin Barlas
5
Damla Kirci
6
İsmail Hakkı Akgün
7
Tansel Yalçın
8
Gamze Düven
9
Duygu Kışla
10
Betül Demirci
11
Gulacti Topcu
12
Ahmet C. Gören
ORCID: 0000-0002-5470-130X
Anahtar Kelimeler
biological activities
Cyprus
GC-MS
LC-HRMS
Propolis
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Ege Üniversitesi
Izmir Turkey
Ege University Faculty of Engineering
Bornova Turkey
Izmir Yüksek Teknoloji Enstitüsü
Izmir Turkey
Yakın Doğu Üniversitesi
Nicosia Cyprus
Metrikler
7
Atıf
12
Yazar
5
Anahtar Kelime