Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Investigation of developmental toxicity and teratogenicity of macrolide antibiotics in cultured rat embryos
Journal of Veterinary Medicine Series C Anatomia Histologia Embryologia · Ekim 2008
YÖKSİS Kayıtları
Investigation of Developmental Toxicity and Teratogenicity of Macrolide Antibiotics in Cultured Rat Embryos
Anatomia, Histologia, Embryologia · 2008 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of developmental toxicity and teratogenicity of macrolide antibiotics in cultured rat embryos
Anat Histol Embryol. · 2008 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Influence of Stomach Volume on the Liver Topography in Cats
2002 ISSN: 0340-2096 SCI 1 atıf
Prof. Dr. EMRULLAH EKEN →
Morphological Studies on Meckel s Diverticulum in Geese Anser Anser Domesticus
2002 ISSN: 0340-2096 SCI 4 atıf
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits Oryctolagus cuniculus
2007 ISSN: 0340-2096 SCI 8 atıf
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys A Stereological Approach
2013 ISSN: 03402096 SSCI
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded 1 atıf
Prof. Dr. SADULLAH BAHAR →
Investigation of Developmental Toxicity and Teratogenicity of Macrolide Antibiotics in Cultured Rat Embryos
2008 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
2013 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Human Fetal Sacral Length Measurement for the Assessment of Fetal Growth and Development by Ultrasonography and Dissection
2001 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. AHMET KAĞAN KARABULUT →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys: A Stereological Approach
2013 ISSN: 03402096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
Morphological Studies on Meckel’s Diverticulum in Geese (Anser Anser Domesticus)
2002 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
Comparative Macroanatomic Investigations of the Venous Drainage of the Heart in Akkaraman Sheep and Angora Goats
2001 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
A three-dimensional reconstructive study of pelvic cavity in the red fox (Vulpes vulpes)
2021 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits (Oryctolagus cuniculus)
2007 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right HorseKidneys A Stereological Approach
2013 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Morphometric analysis of the skull of Hamdani sheep via
Three‐Dimensional
modelling
2022 ISSN: 0340-2096 SCI-Expanded Q2
Prof. Dr. MUSTAFA ORHUN DAYAN →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured title
2013 ISSN: 03402096 SSCI
Prof. Dr. HASAN ACAR →
Calculation of cerebral hemispheres volume values (grey matter, white matter and lateral ventricle) of sheep and goat: A stereological study
2024 ISSN: 0340-2096 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN03402096
Yayın TarihiEkim 2008
Cilt / Sayfa37 · 369-375
Scopus ID2-s2.0-51249113020
Özet
Macrolides are considered to be one of the safest anti-infective groups in clinical use, with severe adverse reactions being rare. However, there are limited data about their embryotoxicity and teratogenicity. We aimed to investigate and compare the effects of these agents on embryonic growth and development. Rat embryos were cultured in vitro for 48 h in rat serum. Whole rat serum was used as a culture medium for the control group while different concentrations of spiramycin and azithromycin (1.25-6.25 μg/ml), and clarithromycin (2.5-30 μg/ml) were added to rat serum for the experimental groups. Dose-dependent effects of macrolides on embryonic developmental parameters were compared using morphological methods. Embryos were evaluated for the presence of any malformations. After morphological examination of the embryos, total DNA was extracted from the cells using standard procedures to determine fragmentation of nuclear DNA of embryonic cells. When compared with the control embryos, the macrolides significantly decreased all growth and developmental parameters dose dependently. While clarithromycin was found to cause more developmental toxicity than spiramycin and azithromycin, azitromycin was determined to have more teratogenicity potential. Compared with controls, there was no difference regarding the fragmentation of nuclear DNA of all the agents used. According to these results, when the toxic and teratogenic potential of the used agents compared, because of the lower toxic and teratogenic effects observed with spiramycin, this agent may be preferred for parturients. © 2008 Blackwell Verlag.
Yazarlar (4)
1
Ahmet Kagan Karabulut
2
Ismihan Ilknur Uysal
3
Hasan Acar
4
Zeliha Fazliogullari
ORCID: 0000-0002-5103-090X
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Q2
SJR Skoru0,317
H-Index46
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
18
Atıf
4
Yazar