Scopus
🔓 Açık Erişim YÖKSİS ISSN Eşleşti
SJR Q3
Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE)
Turkish Journal of Medical Sciences · Ocak 2023
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 48 week response of treatment naive chronic hepatitis B patients to 0 5 mg day entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. ŞUA SÜMER →
Serum Interleukin 8 Levels May Predict Relapse In Brucellosis
2012 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Evaluation of 48 week Response of Treatment Naive Chronic Hepatitis B Patients to 0 5 mg day Entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
The efficacy of intermittant low dose systemic corticosteroid in the treatment of alopecia areata
2004 ISSN: 1300-0144 SCI-Expanded 1 atıf
Prof. Dr. GÜLCAN SAYLAM KURTİPEK →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. HASAN KARA →
Analysis of periprocedural medical complications during carotid angioplasty and stent placement
2010 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
High risk febrile neutropenia and its management in childrenwith solid tumors and lymphoma
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. YAVUZ KÖKSAL →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
Effectiveness of pelvic floor muscle training on symptoms and uroflowmetryparameters in female patients with overactive bladder
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. EVRİM ÇAKMAKÇI →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. NİLSEL OKUDAN →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Refeeding hypophosphatemia a potentially fatal danger in the intensive care unit
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. AYŞEGÜL BAYIR →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Hypo and hypervolemic edema in children with steroid sensitive nephrotic syndrome
2015 ISSN: 13000144 SCI-Expanded Q3
Dr. Öğr. Üyesi MEHMET AKİF BÜYÜKAVCI →
Evaluation of dental technician’s pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings
2017 ISSN: 13000144 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
Cytokeratin 18 and h FABP levels in intestinal ischemia reperfusioninjury role of coenzyme Q10
2013 ISSN: 1300-0144 SSCI 2 atıf
Prof. Dr. NİLSEL OKUDAN →
N terminal pro brain natriuretic peptide levels in children with allergic rhinitis
2016 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2023
Cilt / Sayfa53 · 323-332
Scopus ID2-s2.0-85149131178
Erişim🔓 Açık Erişim
Özet
Background/aim: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs. Materials and methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch. The observation period included three key assessment time points (before the switch, at switch, and after the switch). Data were collected from the MS patients’ database by neurologists between January 2018 and June 2019. The longest follow-up period of the patients was determined as 24 months after the switch. Results: In 462 MS patients that were included in the study, both treatments significantly decreased the number of relapses during the postswitch 12 months versus preswitch one year while patients in the FNG group experienced significantly fewer relapses compared to iDMT cohort in the postswitch 12 months period. FNG cohort experienced fewer relapses than in the iDMT cohort within the postswitch 2 year. The mean time to first relapse after the switch was significantly longer in the FNG group. Conclusion: The present study revealed superior effectiveness of vertical switch over lateral switch regarding the improvement in relapse outcomes. Patients in the FNG cohort experienced sustainably fewer relapses during the follow-up period after the switch compared the iDMT cohort. Importantly, switching to FNG was more effective in delaying time to first relapse when compared with iDMTs.
Yazarlar (43)
1
Aslı Tuncer
2
Murat Kürtüncü
3
Murat Terzi
4
Uğur Uygunoğlu
5
Cansu Goncuoglu
6
Ayşe Nur Yüceyar
7
Özgül Ekmekçi
8
Recai Türkoğlu
9
Aysun Soysal
10
Mesrure Köseoğlu
11
Cavit Boz
12
Yeşim Beckmann
13
Ömer Faruk Turan
14
Meltem Demirkiran
15
Gülşen Akman
16
Burcu Altunrende
17
İlknur Aydin Cantürk
18
Erkingül Birday
19
Abdulcemal Özcan
20
Özden Kamişli
21
Nazire Pınar Acar Özen
22
Rabia Gökçen Gözübatik Çelik
23
Belgin Petek Balci
24
Hüsnü Efendi
25
Cansu Sarikaya
26
Aylin Akçali
27
Münire Kilinç
28
Sibel Canbaz Kabay
29
Ferah Kizilay
30
Serhan Sevim
31
Gülcan Baran Gazaloğlu
32
Caner Feyzi Demir
33
Ferhat Balgetir
34
Nefati Kiylioğlu
35
Hande Sariahmetoğlu
36
Çağcan Ölmez
37
Kamil Mavi
38
Süha Yüksel
39
Nihal Işik
40
Sabahattin Saip
41
Rana Karabudak
42
Aksel Siva
43
Mefküre Eraksoy
Anahtar Kelimeler
beta interferon
disease modifying treatment
Fingolimod
glatiramer acetate
treatment switch
Kurumlar
Akdeniz University, Faculty of Medicine
Antalya Turkey
Aydin Adnan Menderes University
Aydin Turkey
Bakirkoy Research Hospital for Psychiatric and Neurological Diseases
Istanbul Turkey
Başkent Üniversitesi
Ankara Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Ege University Medical School
Izmir Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Florence Nightingale Hospital
Istanbul Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Hacettepe Üniversitesi
Ankara Turkey
Haseki Education and Research Hospital
Istanbul Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Karadeniz Teknik Üniversitesi Tip Fakültesi
Trabzon Turkey
Kocaeli Üniversitesi
İzmit Turkey
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
Mersin Üniversitesi
Mersin Turkey
Novartis Health Food and Agriculture Products Industry and Trade Inc.
Istanbul Turkey
Okan Üniversitesi
Tuzla Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Sultan 2.Abdülhamid Han Eğitim ve Araştirma Hastanesi
Uskudar Turkey
Yalçın City Hospital
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)