Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE)
Turkish Journal of Medical Sciences · Ocak 2023
YÖKSİS Kayıtları
Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE)
Turkish Journal of Medical Sciences · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ CANSU GÖNCÜOĞLU →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa53 · 323-332
Scopus ID2-s2.0-85149131178
Erişim🔓 Açık Erişim
Özet
Background/aim: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs. Materials and methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch. The observation period included three key assessment time points (before the switch, at switch, and after the switch). Data were collected from the MS patients’ database by neurologists between January 2018 and June 2019. The longest follow-up period of the patients was determined as 24 months after the switch. Results: In 462 MS patients that were included in the study, both treatments significantly decreased the number of relapses during the postswitch 12 months versus preswitch one year while patients in the FNG group experienced significantly fewer relapses compared to iDMT cohort in the postswitch 12 months period. FNG cohort experienced fewer relapses than in the iDMT cohort within the postswitch 2 year. The mean time to first relapse after the switch was significantly longer in the FNG group. Conclusion: The present study revealed superior effectiveness of vertical switch over lateral switch regarding the improvement in relapse outcomes. Patients in the FNG cohort experienced sustainably fewer relapses during the follow-up period after the switch compared the iDMT cohort. Importantly, switching to FNG was more effective in delaying time to first relapse when compared with iDMTs.
Yazarlar (43)
1
Aslı Tuncer
2
Murat Kürtüncü
3
Murat Terzi
4
Uğur Uygunoğlu
5
Cansu Goncuoglu
6
Ayşe Nur Yüceyar
7
Özgül Ekmekçi
8
Recai Türkoğlu
9
Aysun Soysal
10
Mesrure Köseoğlu
11
Cavit Boz
12
Yeşim Beckmann
13
Ömer Faruk Turan
14
Meltem Demirkiran
15
Gülşen Akman
16
Burcu Altunrende
17
İlknur Aydin Cantürk
18
Erkingül Birday
19
Abdulcemal Özcan
20
Özden Kamişli
21
Nazire Pınar Acar Özen
22
Rabia Gökçen Gözübatik Çelik
23
Belgin Petek Balci
24
Hüsnü Efendi
25
Cansu Sarikaya
26
Aylin Akçali
27
Münire Kilinç
28
Sibel Canbaz Kabay
29
Ferah Kizilay
30
Serhan Sevim
31
Gülcan Baran Gazaloğlu
32
Caner Feyzi Demir
33
Ferhat Balgetir
34
Nefati Kiylioğlu
35
Hande Sariahmetoğlu
36
Çağcan Ölmez
37
Kamil Mavi
38
Süha Yüksel
39
Nihal Işik
40
Sabahattin Saip
41
Rana Karabudak
42
Aksel Siva
43
Mefküre Eraksoy
Anahtar Kelimeler
beta interferon
disease modifying treatment
Fingolimod
glatiramer acetate
treatment switch
Kurumlar
Akdeniz University, Faculty of Medicine
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Aydin Adnan Menderes University
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Istanbul Turkey
Başkent Üniversitesi
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Ege University Medical School
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Hacettepe Üniversitesi
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Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
İstanbul Tıp Fakültesi
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İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Karadeniz Teknik Üniversitesi Tip Fakültesi
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Kocaeli Üniversitesi
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Kütahya Sağlık Bilimleri Üniversitesi
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Mersin Üniversitesi
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Novartis Health Food and Agriculture Products Industry and Trade Inc.
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Okan Üniversitesi
Tuzla Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Sultan 2.Abdülhamid Han Eğitim ve Araştirma Hastanesi
Uskudar Turkey
Yalçın City Hospital
Istanbul Turkey