Scopus
YÖKSİS Eşleşti
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
Acta Neuropsychiatrica · Ekim 2017
YÖKSİS Kayıtları
Impact of enriched environment on production of tau amyloid precursor protein and amyloid peptide in high fat and high sucrose fed rats
Acta Neuropsychiatrica · 2017 SCI-Expanded
PROFESÖR FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
Acta Neuropsychiatrica · 2017 SCI-Expanded
DOÇENT ALİ KANDEĞER →
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
Acta Neuropsychiatrica · 2017 SCI-Expanded
PROFESÖR FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
Acta Neuropsychiatrica · 2017 SCI-Expanded
PROFESÖR YAVUZ SELVİ →
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
Acta Neuropsychiatrica · 2017 SCI-Expanded
PROFESÖR YAVUZ SELVİ →
Impact of enriched environment on production of tau amyloid precursor protein and amyloid peptide in high fat and high sucrose fed rats
Acta Neuropsychiatrica · 2016 SCI-Expanded
PROFESÖR YAVUZ SELVİ →
Makale Bilgileri
DergiActa Neuropsychiatrica
Yayın TarihiEkim 2017
Cilt / Sayfa29 · 291-298
Scopus ID2-s2.0-85001610082
Özet
Objective The Western-Type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid β-peptide (Aβ) (1-40), Aβ(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results The EE decreased the Aβ(1-40), Aβ(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion This observation shows that EE may rescue diet-induced amyloid and tau pathology.
Yazarlar (8)
1
Yavuz Selvi
2
Hasan Serdar Gergerlioglu
3
Nursel Akbaba
4
Mehmet Öz
5
Ali Kandeger
ORCID: 0000-0001-6940-0940
6
Enver Ahmet Demir
7
Fatma Humeyra Yerlikaya
8
Kismet Esra Nurullahoglu-Atalik
Anahtar Kelimeler
Alzheimer's disease
amyloid
diet
hippocampus
tau
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
18
Atıf
8
Yazar
5
Anahtar Kelime