Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Effects of BCRP and P-gp modulators on the penetration of aflatoxin B1 into the mouse brain
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2017
YÖKSİS Kayıtları
Aflatoksin B1’in Fare Beynine Geçişi Üzerine BCRP ve P-gp Modülatörlerinin Etkisi
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Effects of BCRP and P-gp Modulators on the Penetration of Aflatoxin B-1 into the Mouse Brain
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
Prof. Dr. BURAK DİK →
Aflatoksin B1’in Fare Beynine Geçişi Üzerine BCRP ve P-gp Modülatörlerinin Etkisi
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
Prof. Dr. BÜNYAMİN TRAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI-Expanded
Doç. Dr. ÖZCAN ŞAHİN →
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI Q3
Doç. Dr. ÖZCAN ŞAHİN →
Hayvan Koruma Kavramı ve Biyoetik Çerçevesinde Yaban Hayatı Koruma ve Yaban Hayatı Geliştirme Sahaları
2012 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Anatomy of the Cervical Canal in the Angora Goat Capra hircus
2010 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
2013 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Prevalence of Bartonella henselae in Pet and Stray Cats from the Aspect of Public Health: A Research Sample in the Concept of One Medicine - One Health
2015 ISSN: 1300-6045 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Fatty Acid Composition and Conjugated Linoleic Acid CLA Content of Some Commercial Milk in Turkey
2010 ISSN: 1300-6045 SCI-Expanded 5 atıf
Prof. Dr. GÖKHAN ZENGİN →
The potential of microarray databases to identify tissue specific genes
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
An Application of Bootstrap Technique in Animal Science EggYolk Color Sample
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. RAMAZAN ÇÖL →
The Effect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded Q4
Doç. Dr. ARİFE EZGİ TELLİ →
Türkiye’de Deney Hayvanı Kullanmaya Yetkili Kişilerin Hayvan Kullanımına Yönelik Tutumları
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
TheEffect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÜMİT GÜRBÜZ →
Structural and Functional Properties of the Distal Muscles ofFront and Hind Legs of Malakan Horses (Equus caballus)
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA ORHUN DAYAN →
A Comparison of Different Analysis Methods for Milk Urea Nitrogen
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA SELÇUK ALATAŞ →
Effects of Dietary Inactive Yeast and Live Yeast on Performance Egg Quality Traits Some Blood Parameters and Antibody Production to SRBC of Laying Hens
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
Prof. Dr. AŞKIN YAŞAR →
Etanersept endotoksemi tedavisinde kullanılabilir mi
2013 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
ISSN13006045
Yayın TarihiOcak 2017
Cilt / Sayfa23 · 95-100
Scopus ID2-s2.0-84993990705
Özet
This study was conducted to determine whether the plasma and brain concentrations of AFB1 are affected by the modulation of P-gp and BCRP using zosuquidar (ZQR) and prazosin (PRZ), respectively. In this study, a total of 40 healthy adult male BALB/c mice (32±3.7 g) were used. The animals were randomly divided into 5 groups, with 8 animals per group. Group 1 was used for method validation. Group 2 (AF) received intraperitoneal AFB1 at a dose of 20 mg/kg of body weight. Groups 3 (AF+PRZ), 4 (AF+ZQR), and 5 (AF+PRZ+ZQR) received 20 mg/kg of AFB1 intraperitoneally 30 min after the intraperitoneal administration of prazosin (0.3 mg/kg), zosuquidar (25 mg/kg), and prazosin+zosuquidar (0.3 mg/kg prazosin + 25 mg/kg zosuquidar), respectively. Six hours after the administration of AFB1, blood and brain samples were collected from the animals in Groups 2 to 5. AFB1 concentrations were determined using an HPLC system with fluorescence detection. Individual and simultaneous administration of prazosin and zosuquidar significantly reduced the brain concentrations of AFB1 in comparison to a single administration of AFB1 (P<0.05). The brain/plasma ratio of the AF group was higher than that of the other groups (AF+PRZ, AF+ZQR, and AF+PRZ+ZQR) (P<0.05). Inducers of transmembrane proteins, especially BCRP, can be life saving during acute AFB1 poisoning.
Yazarlar (6)
1
B. Traş
2
Gul Cetin
3
Kamil Üney
ORCID: 0000-0002-8674-4873
4
Burak Dik
5
Orhan Corum
ORCID: 0000-0003-3168-2510
6
Sema Atalay
Anahtar Kelimeler
Aflatoxin B 1
Brain
Drug transporter proteins
Mice
Modulation
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Energy Inc.
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
7
Atıf
6
Yazar
5
Anahtar Kelime