Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
Tropical Animal Health and Production · Şubat 2019
YÖKSİS Kayıtları
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
TROPICAL ANIMAL HEALTH AND PRODUCTION · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
Tropical Animal Health and Production · 2019 SCI-Expanded
Prof. Dr. MEHMET MADEN →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
TROPICAL ANIMAL HEALTH AND PRODUCTION · 2019 SCI
Prof. Dr. BÜNYAMİN TRAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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The role of goats as reservoir hosts for bovine herpes virus 1 under field conditions
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Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
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Prof. Dr. MEHMET MADEN →
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Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
2019 ISSN: 0049-4747 SCI
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
2019 ISSN: 0049-4747 SCI
Prof. Dr. BÜNYAMİN TRAŞ →
Effect of embryo quality and developmental stages on pregnancy rate during fresh embryo transfer in beef heifers
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2021 ISSN: 0049-4747 SCI-Expanded Q2
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Relationships between FAMACHA© scores and parasite incidence in sheep and goats
2021 ISSN: 0049-4747 SCI-Expanded Q2
Prof. Dr. ALİ KARABACAK →
Relationships between FAMACHA© scores and parasite incidence in sheep and goats
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Sepiolite as an effective supplement for low-protein diets with the constant energy-protein ratio in broilers
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Effect of maca powder supplementation to growing quail diets on performance, carcass, serum constituents and hormones, and bone and ileum characteristics
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Effect of inseminator on reproductive performance in dairy cattle
2022 ISSN: 0049-4747 SCI-Expanded Q2
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2022 ISSN: 0049-4747 SCI-Expanded Q2
Prof. Dr. BİROL DAĞ →
Makale Bilgileri
ISSN00494747
Yayın TarihiŞubat 2019
Cilt / Sayfa51 · 435-441
Scopus ID2-s2.0-85053618278
Özet
This study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10 mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2 h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24 h following the drug administration were significantly different from the control values (0 h) (P < 0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 ± 0.19 h), a large volume of distribution (6.30 ± 1.76 L/kg), and high total body clearance (5.31 ± 1.27 L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10 mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX.
Yazarlar (5)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
B. Traş
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
Ramazan Yildiz
5
Mehmet Maden
Anahtar Kelimeler
Cattle
Intravenous
M-I metabolite
Pentoxifylline
Pharmacokinetics
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Tropical Animal Health and Production
Q2
SJR Skoru0,472
H-Index73
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Animal Science and Zoology (Q2)
Food Animals (Q2)
Metrikler
7
Atıf
5
Yazar
5
Anahtar Kelime