Scopus
YÖKSİS Eşleşti
Treatment and protective effects of metalloproteinase inhibitors alone and in combination with N-Acetyl cysteine plus vitamin E in rats exposed to aflatoxin B<inf>1</inf>
Toxicon · Nisan 2021
YÖKSİS Kayıtları
Treatment and protective effects of metalloproteinase inhibitors alone and in combination with N-Acetyl cysteine plus vitamin E in rats exposed to aflatoxin B1
Toxicon · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Treatment and protective effects of metalloproteinase inhibitors alone and in combination with N-Acetyl cysteine plus vitamin E in rats exposed to aflatoxin B1
Toxicon · 2021 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
Treatment and protective effects of metalloproteinase inhibitors alone and in combination with N-Acetyl cysteine plus vitamin E in rats exposed to aflatoxin B1
Toxicon · 2021 SCI-Expanded
PROFESÖR BURAK DİK →
Treatment and protective effects of metalloproteinase inhibitors alone and in combination with N-Acetyl cysteine plus vitamin E in rats exposed to aflatoxin B1
Toxicon · 2021 SCI-Expanded
PROFESÖR BANU BOZKURT →
Makale Bilgileri
DergiToxicon
Yayın TarihiNisan 2021
Cilt / Sayfa194 · 79-85
Scopus ID2-s2.0-85101618523
Özet
This study was conducted to investigate the effects of matrix metalloproteinase (MMP) inhibitors dexamethasone and minocycline administrations —both single and in combination with N-acetylcysteine (NAC) and vitamin E—on the tissue distribution and lethal dose (LD)50 of aflatoxin (AF)B1 in rats. We performed this study on male Wistar rats (8–10 weeks) in two phases. In the first phase, rats were administered dexamethasone (5 and 20 mg/kg) and minocycline (45 and 90 mg/kg), both as single treatments and in combination with NAC (200 mg/kg) and vitamin E (600 mg/kg); these treatments followed AFB1 administration (2 mg/kg). In the second phase, the therapeutic effect value (TEV) was calculated to determine the treatment effect on the LD50 level of AFB1. The tissue affinity of AFB1 from high to low was liver, kidney, intestine, brain, heart, spleen, lung, testis, and vitreous humor, respectively. Dexamethasone at the 20 mg/kg dose significantly reduced AFB1 concentrations in the plasma and the other tissues, except for the vitreous humor. The effects of minocycline on the plasma and tissue concentrations of AFB1 varied by dose and tissue. The combinations of dexamethasone or minocycline with NAC and vitamin E increased the AFB1 concentrations in the plasma and all tissues, except for vitreous humor and liver. In male rats, the LD50 value of AFB1 was 11.86 mg/kg. The TEV of dexamethasone (20 mg/kg) was calculated to be 1.5. Dexamethasone can be administered in repeated doses at ≥20 mg/kg to increase survival in AFB1 poisoning.
Yazarlar (7)
1
B. Traş
2
H. Eser Faki
3
Zeynep Ozdemir Kutahya
4
Emre Bahcivan
5
Burak Dik
6
Banu Bozkurt
ORCID: 0000-0002-9847-3521
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Aflatoxin B 1
Dexamethasone
Minocycline
Rat
Tissue concentration
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Kafkas Üniversitesi, Veteriner Fakültesi
Kars Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
7
Yazar
5
Anahtar Kelime