Scopus
YÖKSİS Eşleşti
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
Canadian Journal of Physiology and Pharmacology · Ocak 2023
YÖKSİS Kayıtları
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
Canadian journal of physiology and pharmacology · 2023 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
Canadian Science Publishing · 2023 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
Canadian Journal of Physiology and Pharmacology · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Makale Bilgileri
DergiCanadian Journal of Physiology and Pharmacology
Yayın TarihiOcak 2023
Cilt / Sayfa101 · 475-480
Scopus ID2-s2.0-85169503727
Özet
This study aimed to determine the effect of administration of oral vitamins A and E at different doses on plasma and brain concentrations of ivermectin in mice. The study was carried out on 174 Swiss Albino male mice aged 8-10 weeks. After leaving six mice for method validation, the remaining mice were randomly divided into seven groups with equal numbers of animals. Mice received ivermectin (0.2 mg/kg, subcutaneous) alone and in combination with low (vitamin A: 4000 IU/kg; vitamin E: 35 mg/kg) and high (vitamin A: 30 000 IU/kg; vitamin E: 500 mg/kg) oral doses of vitamins A and E. The plasma and brain concentrations of ivermectin were measured using high-performance liquid chromatography-fluorescence detector. We determined that high doses of vitamins A and E and their combinations increased the passing ratio of ivermectin into the brain significantly. The high-dose vitamin E and the combination of high-concentration vitamins E andA significantly increased the plasma concentration of ivermectin (P < 0.05). The high-dose vitamins E andA and their high-dose combination increased the brain concentration of ivermectin by 3, 2, and 2.7 times, respectively. This research is the first in vivo study to determine the interaction between P-gp substrates and vitamins E and A.
Yazarlar (4)
1
B. Traş
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
T. M. Parlak
4
Oznur Tufan
Anahtar Kelimeler
drug disposition
ivermectin
mice
vitamin A
vitamin E
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey