Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
The effect of low- and high-dose levothyroxine on the expression, protein level, and function of P-glycoprotein in mice
Journal of the Hellenic Veterinary Medical Society · Ocak 2023
YÖKSİS Kayıtları
The effect of low- and high-dose levothyroxine on the expression, protein level, and function of P-glycoprotein in mice
Journal of the Hellenic Veterinary Medical Society · 2023 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
The effect of low- and high-dose levothyroxine on the expression, protein level, and function of P-glycoprotein in mice
Journal of the Hellenic Veterinary Medical Society · 2023 SCI-Expanded
Prof. Dr. BÜNYAMİN TRAŞ →
The effect of low- and high-dose levothyroxine on the expression, protein level, and function of P-glycoprotein in mice
Journal of the Hellenic Veterinary Medical Society · 2023 SCI-Expanded
Dr. Öğr. Üyesi TUĞBA MELİKE PARLAK →
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Makale Bilgileri
ISSN17922720
Yayın TarihiOcak 2023
Cilt / Sayfa74 · 6247-6255
Scopus ID2-s2.0-85175169881
Erişim🔓 Açık Erişim
Özet
The study was investigated the effect of different doses of levothyroxine on the mRNA expression, protein level and function of P-glycoprotein. Mice were divided into 6 groups as control, low dose levothyroxine, high dose levothyroxine, fexofenadine, low dose levothyroxine+fexofenadine and high dose levothyroxine+fexofenadine. Mice received levothyroxine at doses of 8 and 80 μg/kg daily for 21 days. Fexofenadine was administered at dose of 40 mg/kg at the 24 h following the last administration of levothyroxine. The mRNA levels and protein level of P-glycoprotein in liver and small intestine were determined by RT-PCR and western blot analysis, respectively. Plasma concentrations of fexofenadine were determined using HPLC. Levothyroxine at low and high doses caused an insignificant increase intestinal mRNA expression of mdr1a, while high dose levothyroxine+fexofenadine caused a significant increase. Levothyroxine caused a dose-dependent decrease in intestinal mRNA expression of mdr1b. In liver, levothyroxine caused a dose-dependent increase in the mRNA expression of mdr1a. Fexofenadine significantly reduced the effect of levothyroxine on mRNA expression of mdr1a in liver. Levothyroxine increased the protein level of P-glycoprotein in liver and decrease in intestines. Low dose levothyroxine significantly increased the plasma concentration of fexofenadine. The effects of levothyroxine on the mRNA expression of mdr1a and b in small intestine and liver and protein level of P-glycoprotein varied depending on the dose, tissue type, and fexofenadine administration.
Yazarlar (5)
1
B. Traş
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
Hatice Eser Faki
4
T. M. Parlak
5
Zeynep Ozdemir Kutahya
Anahtar Kelimeler
fexofenadine
levothyroxine
mRNA
P-glycoprotein
protein level
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of the Hellenic Veterinary Medical Society
Q3
SJR Skoru0,200
H-Index18
YayıncıHellenic Veterinary Medical Society
ÜlkeGreece
Veterinary (miscellaneous) (Q3)