Scopus
YÖKSİS Eşleşti
Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats
Journal of the Hellenic Veterinary Medical Society · Ocak 2024
YÖKSİS Kayıtları
Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats Survival rate in tilmicosin toxicity
Journal of the Hellenic Veterinary Medical Society · 2024 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin induced toxicity by electrocardiography and biochemical parameters in goats
Journal of the Hellenic Veterinary Medical Society · 2024 SCOPUS
PROFESÖR BURAK DİK →
Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats Survival rate in tilmicosin toxicity
Journal of the Hellenic Veterinary Medical Society · 2024 SCI-Expanded
DOÇENT AMİR NASERİ →
Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats: Survival rate in tilmicosin toxicity.
Journal of the Hellenic Veterinary Medical Society · 2024 SCI-Expanded
DOÇENT MERVE İDER →
Makale Bilgileri
DergiJournal of the Hellenic Veterinary Medical Society
Yayın TarihiOcak 2024
Cilt / Sayfa75 · 7081-7088
Scopus ID2-s2.0-85194910804
Özet
Tilmicosin shows different degrees of cardiotoxic effect in various animal species depending on the route of administration and dose. We aimed to determine the effects of amiodarone and amiodarone+dobutamine treatments on tilmicosincardiotoxicity and survival time. 18 healthy goats were divided into tilmicosin, tilmicosin+amiodarone and tilmicosin+amiodarone+dobutamine groups. After drug administrations, the survival times of the animals in all groups were recorded. In addition, blood was drawn from the animals just before they died. Haemogram, troponin I, CK-MB, and other biochemical parameters were measured in all blood samples. Prolonged survival was observed in the treatment groups compared to the tilmicosin group. In the treatment groups, decreases in haemogram parameters, albumin, and total protein levels caused by tilmicosin could not be prevented, while the increase in troponin I level was prevented. In conclusion, while cardiotoxicity due to high troponin from tilmicosin was prevented, the survival rate was not affected in both treatment groups, and the survival time was extended at differing rates. In case of accidental or deliberate overdose of tilmicosin in animals, in addition to the use of amiodarone+dobutamine, the survival time may be prolonged, and the success may increase if the necessary symptomatic treatments and equipment support are available.
Yazarlar (7)
1
Devran Coskun
ORCID: 0000-0003-1151-1861
2
Merve Ider
ORCID: 0000-0003-2928-5452
3
Amir Naseri
4
Burak Dik
5
Emre Bahcivan
6
B. Traş
7
A. Er
Anahtar Kelimeler
Amiodarone
Cardiotoxicity
Dobutamine
Survival time
Tilmicosin
Kurumlar
Amasya Üniversitesi
Amasya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey