Scopus
YÖKSİS Eşleşti
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
Hormone Molecular Biology and Clinical Investigation · Mayıs 2018
YÖKSİS Kayıtları
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
Hormone Molecular Biology and Clinical Investigation · 2018 Emerging Sources Citation Index
PROFESÖR SÜLEYMAN PATLAR →
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2018 ESCI: Emerging Sources Citation Index
PROFESÖR RASİM MOĞULKOÇ →
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2018 ESCI: Emerging Sources Citation Index
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiMayıs 2018
Cilt / Sayfa34
Scopus ID2-s2.0-85045511554
Özet
Aim: The present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise. Methods: The study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control. In order to induce diabetes, the animals were subcutaneously injected with 40 mg/kg streptozotocin (STZ). The animals were supplemented with 3 mg/kg/day melatonin intraperitoneally (IP) for 4 weeks. At the end of the study, the animals were decapitated to collect bone tissue samples which were examined to find out the malondialdehyde (MDA) (nmol/g/protein) and glutathione (GSH) (mg/dL/g protein) levels. Results: The highest MDA values in the bone tissue were found in groups 7 and 8. MDA levels in the bone tissue in groups 3 and 6 were lower than the levels in groups 7 and 8, but higher than those in all other groups. Groups 3, 5 and 6 had the highest bone tissue GSH values. On the other hand, the lowest GSH level was established in groups 7 and 8. Conclusion: The results of the present study indicated that the cell damage caused by acute swimming exercise and diabetes in the bone tissue could be prevented by melatonin supplementation.
Yazarlar (5)
1
Mursel Bicer
2
Saltuk Bugra Baltaci
3
Süleyman Patlar
ORCID: 0000-0003-3817-3575
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
bone tissue
diabetic rats
exercise
lipid peroxidation
melatonin supplementation
Kurumlar
Gaziantep Üniversitesi
Gaziantep Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
5
Yazar
5
Anahtar Kelime