Scopus
YÖKSİS DOI Eşleşti
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
Hormone Molecular Biology and Clinical Investigation · Mayıs 2018
YÖKSİS Kayıtları
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2018 ESCI: Emerging Sources Citation Index
Prof. Dr. RASİM MOĞULKOÇ →
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2018 ESCI: Emerging Sources Citation Index
Prof. Dr. ABDULKERİM KASIM BALTACI →
Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
Hormone Molecular Biology and Clinical Investigation · 2018 Emerging Sources Citation Index
Prof. Dr. SÜLEYMAN PATLAR →
Makale Bilgileri
Dergi
Hormone Molecular Biology and Clinical Investigation
Yayın TarihiMayıs 2018
Cilt / Sayfa34
Scopus ID2-s2.0-85045511554
Özet
Aim: The present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise. Methods: The study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control. In order to induce diabetes, the animals were subcutaneously injected with 40 mg/kg streptozotocin (STZ). The animals were supplemented with 3 mg/kg/day melatonin intraperitoneally (IP) for 4 weeks. At the end of the study, the animals were decapitated to collect bone tissue samples which were examined to find out the malondialdehyde (MDA) (nmol/g/protein) and glutathione (GSH) (mg/dL/g protein) levels. Results: The highest MDA values in the bone tissue were found in groups 7 and 8. MDA levels in the bone tissue in groups 3 and 6 were lower than the levels in groups 7 and 8, but higher than those in all other groups. Groups 3, 5 and 6 had the highest bone tissue GSH values. On the other hand, the lowest GSH level was established in groups 7 and 8. Conclusion: The results of the present study indicated that the cell damage caused by acute swimming exercise and diabetes in the bone tissue could be prevented by melatonin supplementation.
Yazarlar (5)
1
Mursel Bicer
2
Saltuk Bugra Baltaci
3
Süleyman Patlar
ORCID: 0000-0003-3817-3575
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
bone tissue
diabetic rats
exercise
lipid peroxidation
melatonin supplementation
Kurumlar
Gaziantep Üniversitesi
Gaziantep Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
5
Yazar
5
Anahtar Kelime