Scopus
YÖKSİS Eşleşti
Effects of magnesium sulfate on tissue lactate and malondialdehyde levels after cerebral ischemia
Pharmacology · Haziran 2003
YÖKSİS Kayıtları
Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels after Cerebral Ischemia
Pharmacology · 2003 SCI-Expanded
PROFESÖR AHMET AK →
Makale Bilgileri
DergiPharmacology
Yayın TarihiHaziran 2003
Cilt / Sayfa68 · 162-168
Scopus ID2-s2.0-0038693410
Özet
In the present study, the effects of magnesium sulfate on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia in rabbits were studied. The rabbits were divided equally into three groups. Group 1 (n = 8) was the sham-operated control group, in group 2 (n = 8) only cerebral ischemia was induced by clamping bilaterally the common carotid arteries for 60 min, and in group 3 (n = 8) magnesium sulfate was administered at a dose of 100 mg/kg i.v. within 5 min after opening the clamps. In group 1 EEG recordings were obtained immediately and 60 and 120 min after craniectomy. In groups 2 and 3 EEG recordings were obtained immediately after craniectomy but before clamping and 60 min after clamping. One hour after opening the clamps and taking EEG recordings, brain cortices were resected, and the concentrations of lactate and MDA were determined using spectrophotometric/enzymatic and thiobarbituric acid methods, respectively. In all groups, there were significant differences between MDA and lactate levels (p < 0.05). There were no significant differences in lactate levels between groups 2 and 3 (p > 0.05), and also the preischemic EEG grades were the same in all groups. Preischemic and postischemic EEG values were significantly different (p < 0.05), and there were also significant differences between postischemic EEG grades in groups 2 and 3 (p < 0.05). There was a correlation between postischemic EEG grades and MDA and lactate levels. These results demonstrate that cerebral ischemia-reperfusion injury leads to an increase in brain tissue lactate and MDA levels, that magnesium sulfate suppresses the increase of MDA and lactate concentrations, and that magnesium sulfate treatment improves the EEG changes. The EEG grades correlated well with MDA and lactate levels. Copyright © 2003 S. Karger AG, Basel.
Yazarlar (6)
1
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
2
Mehmet E. Ustün
3
Ahmet Ak
4
Alper Yosunkaya
5
H. B. Ulusoy
6
Mehmet Gürbilek
Anahtar Kelimeler
Cerebral ischemia
Lactate
Lipid peroxidation
Magnesium sulfate
Malondialdehyde
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
22
Atıf
6
Yazar
5
Anahtar Kelime