Scopus
YÖKSİS ISSN Eşleşti
SJR Q2
The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta
Fundamental and Clinical Pharmacology · Aralık 2007
YÖKSİS Kayıtları — ISSN Eşleşmesi
Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
2013 ISSN: 07673981 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
The effects of dexketoprofen on duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block with levobupivacaine
2014 ISSN: 07673981 SCI-Expanded
Prof. Dr. JALE BENGİ ÇELİK →
The effects of dexketoprofen on duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block with levobupivacaine
2014 ISSN: 0767-3981 SCI-Expanded
Prof. Dr. HÜLAGU BARIŞKANER →
Single and repeated sevoflurane or desflurane exposure does not impairspatial memory performance of young adult mice
2013 ISSN: 0767-3981 SSCI
Prof. Dr. NİLSEL OKUDAN →
The effects of dexketoprofen on duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block with levobupivacaine
2014 ISSN: 0767-3981 index medicus
Prof. Dr. İNCİ KARA →
The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta
2007 ISSN: 0767-3981 SCI-Expanded
Prof. Dr. HÜLAGU BARIŞKANER →
Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus
2024 ISSN: 0767-3981 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The comparison of the antidiabetic effects of exenatide, empagliflozin, quercetin, and combination of the drugs in type 2 diabetic rats
2024 ISSN: 0767-3981 SCI-Expanded Q3
Prof. Dr. BURAK DİK →
Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus
2024 ISSN: 0767-3981 SCI-Expanded Q3
Prof. Dr. AYŞE ER →
Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus
2024 ISSN: 0767-3981 SCI-Expanded Q3
Prof. Dr. BURAK DİK →
Makale Bilgileri
ISSN07673981
Yayın TarihiAralık 2007
Cilt / Sayfa21 · 595-600
Scopus ID2-s2.0-36349014198
Özet
In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10-12-10 -9 m) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10-6 m). Removal of endothelium abolished the effects of leptin. Pretreatment of rings with N ω-nitro-l-arginine methyl ester (10-4 m 20 min) or catalase (1200 U/mL 20 min) significantly reduced the relaxant response to leptin when compared with the control group. The incubation of brefeldin A (3.5 × 10-5 m 90 min), indomethacin (10-5 m 20 min), tetraethylammonium (10-4 m 20 min), and glibenclamide (10 -5 m, 20 min) did not affect the leptin-induced vasodilation. These results suggest that leptin relaxes the rabbit aorta. The relaxation is mediated by endothelium-derived nitric oxide and hydrogen peroxide. © 2007 The Authors.
Yazarlar (2)
1
Ayşe Saide Şahin
2
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
Anahtar Kelimeler
H O 2 2
Leptin
Nitric oxide
Rabbit aorta
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fundamental and Clinical Pharmacology
Q2
SJR Skoru0,689
H-Index89
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Pharmacology (Q2)
Pharmacology (medical) (Q2)
Metrikler
28
Atıf
2
Yazar
4
Anahtar Kelime