Scopus
🔓 Açık Erişim
The effect of tramadol on the rat sciatic nerve conduction: A numerical analysis and conduction velocity distribution study
Yakugaku Zasshi · Nisan 2009
Makale Bilgileri
DergiYakugaku Zasshi
Yayın TarihiNisan 2009
Cilt / Sayfa129 · 485-493
Scopus ID2-s2.0-66149124525
Erişim🔓 Açık Erişim
Özet
The aim of this study was to document the effect of tramadol as an opioid on individual fibers of rat sciatic nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated nerves treated with tramadol from five different concentration levels. Then recorded CAPs and the control group were analyzed by numerical methods namely Conduction Velocity Distribution (CVD) and Fast Fourier Transform (FFT). The results show that the area under CAP and the time derivative of CAP curves decreases, and the excitability of the nerve trunk falls as well (rheobase and chronaxie increases) with increasing tramadol concentration. CVD deduced by model study was divided into subgroups as SLOW (8-26 m/s), MODERATE (26-44 m/s), MEDIUM (44-60 m/s) and FAST (60-78 m /s). The decrement in percentage relative contribution of these conduction velocity groups starts with a concentration of 0.25 mM tramadol, especially in the subgroup named FAST. The power spectrum shifts from higher frequency region to lower frequency region as the tramadol concentration increases. These findings show that fast conducting fibers are more susceptible to tramadol than medium and moderate groups and tramadol possibly acts on channel activity rather than passive properties (such as space and time constant) of nerve fibers. © 2009 The Pharmaceutical Society of Japan.
Yazarlar (4)
1
Nizamettin Dalkilic
2
Seckin Tuncer
3
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
4
Erhan Kiziltan
Anahtar Kelimeler
Compound action potential
Conduction velocity distribution
Rat sciatic nerve
Tramadol
Kurumlar
Middle East Technical University (METU)
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
21
Atıf
4
Yazar
4
Anahtar Kelime