Scopus
YÖKSİS Eşleşti
The effect of supplementation of grape seed proanthocyanidin extract on vascular dysfunction in experimental diabetes
Journal of Medicinal Food · Kasım 2011
YÖKSİS Kayıtları
The Effect of Supplementation of Grape Seed Proanthocyanidin Extract onVascular Dysfunction in Experimental Diabetes
JOURNAL OF MEDICINAL FOOD · 2011 SSCI 15 atıf
PROFESÖR NİLSEL OKUDAN →
The Effect of Supplementation of Grape Seed Proanthocyanidin Extract on Vascular Dysfunction in Experimental Diabetes
Journal of Medicinal Food · 2011 SCI
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiJournal of Medicinal Food
Yayın TarihiKasım 2011
Cilt / Sayfa14 · 1298-1302
Scopus ID2-s2.0-80755125257
Özet
Increased oxidative stress and impaired endothelium-dependent relaxation could underlie many of the vascular complications associated with diabetes. We aimed to investigate the effect of supplementation with grape seed proanthocyanidin extract (GSPE), a natural antioxidant, on vascular responses and oxidative stress in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into three groups: control rats, untreated diabetic rats, and GSPE (100mg/kg, for 6 weeks)-supplemented diabetic rats. Thoracic aorta rings of the rats were mounted in organ baths, and relaxant responses to acetylcholine (ACh), A23187, and sodium nitroprusside (SNP) were assayed in tissues precontracted with 60mM KCl. Plasma samples used for the measurement of malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. The endothelium-dependent relaxations in response to ACh and A23187 were impaired, but endothelium-independent relaxation in response to SNP did not change in diabetic rats. Supplementation with GSPE significantly improved the relaxant responses to ACh and A23187. The MDA level was significantly elevated and the plasma SOD activity was decreased in diabetic rats, but supplementation with GSPE attenuated the elevated MDA levels and increased plasma SOD activity. Thus supplementation of GSPE may attenuate oxidative stress through the inhibition of lipid peroxidation and may restore endothelial function and reduce the risk of vascular disease in diabetes. © Copyright 2011, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2011.
Yazarlar (6)
1
Nilsel Okudan
2
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
3
H. Gökbel
4
Ayşe Saide Şahin
5
Muaz Belviranli
6
Hatice Baysal
Anahtar Kelimeler
diabetes
grape seed proanthocyanidins
vascular endothelium
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
30
Atıf
6
Yazar
3
Anahtar Kelime